Accrued expenses - Schedule of Accrued Expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Employee compensation and related benefits	$ 2,280	$ 6,050
Accrued external research and development expenses	5,361	5,041
Professional fees	1,237	1,109
Other	2,055	792
Total	$ 10,933	$ 12,992