X0306 4 2021-06-21 1 0001840574 Verve Therapeutics, Inc. VERV 0001595725 Rock Springs Capital Management LP 650 SOUTH EXETER ST., SUITE 1070 BALTIMORE MD 21202 0 0 1 0 0001735393 Rock Springs Capital Master Fund LP C/O WALKERS CORPORATE LIMITED, CAYMAN CO CENTER 27 HOSPITAL ROAD GEORAGE TOWN E9 KY-1-9008 CAYMAN ISLANDS 0 0 1 0 0001735397 Rock Springs Capital LLC 650 SOUTH EXETER ST., SUITE 1070 BALTIMORE MD 21202 0 0 1 0 Common Stock 2021-06-21 4 C 0 556298 A 556298 I See Footnote Common Stock 2021-06-21 4 P 0 370000 19.00 A 926298 I See Footnote Common Stock 2021-06-21 4 C 0 152926 A 152926 I See Footnote Series B Preferred Stock 2021-06-21 4 C 0 5151043 D Common Stock 556298 0 I See Footnote Series B Preferred Stock 2021-06-21 4 C 0 1416023 D Common Stock 152926 0 I See Footnote The Series B Preferred Stock converted into shares of the Issuer's common stock, $0.001 par value, on an approximately 9.2595:1 basis automatically immediately prior to the closing of the Issuer's initial public offering. The Series B Preferred Stock had no expiration date. The securities reported herein are held of record by Rock Springs Capital Master Fund LP ("Master Fund"). Rock Springs Capital LLC ("RSC") is the general partner of Rock Springs Capital Management LP ("RSCM") which is the investment manager to Master Fund. RSC and RSCM may therefore be deemed to have or share beneficial ownership of the shares held directly by Master Fund. The securities reported herein are held of record by Four Pines Master Fund LP ("Four Pines"). RSC is the general partner of RSCM which is the investment manager to Four Pines. RSC and RSCM may therefore be deemed to have or share beneficial ownership of the shares held directly by Four Pines. Rock Springs Capital Management LP, By: /s/ Graham McPhail, Authorized Signatory 2021-06-22 Rock Springs Capital Master Fund LP, By: /s/ Graham McPhail, Authorized Signatory 2021-06-22 Rock Springs Capital LLC, By: /s/ Graham McPhail, Authorized Signatory 2021-06-22