SCHEDULE 13G/A 0001455767 XXXXXXXX LIVE 4 Common Stock, $0.0001 par value 12/31/2025 0001840439 Biomea Fusion, Inc. 09077A106 1599 Industrial Road San Carlos CA 94070 Rule 13d-1(d) Rainer M. Erdtmann b X1 2782707 0 2782707 0 2782707 N 3.9 IN Biomea Fusion, Inc. 1599 Industrial Road, San Carlos, CA 94070 This statement is filed by Rainer M. Erdtmann, a citizen of the United States of America, with respect to the shares of common stock of Biomea Fusion, Inc. (the "Company"), par value $0.0001 per share (the "Shares"). The address of the principal business office of Rainer M. Erdtmann is c/o Biomea Fusion, Inc., 1599 Industrial Road, San Carlos, CA 94070. See Item 2(a) above. N Rainer M. Erdtmann may be deemed to beneficially own 2,782,707 Shares, consisting of: (i) 690,677 Shares issuable upon the exercise of stock options exercisable within 60 days held directly by Rainer M. Erdtmann, (ii) 572,427 shares held directly by Rainer M. Erdtmann, (iii) an aggregate of 210,000 Shares held by the children of Rainer M. Erdtmann, (iv) 174,614 Shares held by a trust with an independent trustee ("Trust 1"); and (v) 1,134,989 Shares held by a separate trust with an independent trustee ("Trust 2"). Effective December 19, 2025, the Reporting Person resigned as a Managing Member of Point Sur Investors, LLC, the general partner of Point Sur Investors Fund I, LP and no longer may be deemed a beneficial owner of any of the Issuer's securities held directly by Point Sur Investors Fund I, LP and Point Sur Investors, LLC. The percent of class of the outstanding Shares beneficially owned by the Reporting Person in Item 4(a) is based on (i) 70,703,639 shares of Common Stock outstanding as of October 31, 2025, as disclosed in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 4, 2025 and (ii) 690,677 Shares issuable within 60 days after December 31, 2025 upon the exercise of options held directly by Rainer M. Erdtmann, which have been added to the Shares reported as outstanding in accordance with Rule 13d-3(d)(1)(i) under the Securities Exchange Act of 1934. The information required by this Item 4(c)(i) is set forth in Row 5 of the cover page for the Reporting Person hereto and is incorporated herein by reference for the Reporting Person. The information required by this Item 4(c)(ii) is set forth in Row 6 of the cover page for the Reporting Person hereto and is incorporated herein by reference for the Reporting Person. The information required by this Item 4(c)(iii) is set forth in Row 7 of the cover page for the Reporting Person hereto and is incorporated herein by reference for the Reporting Person. The information required by this Item 4(c)(iv) is set forth in Row 8 of the cover page for the Reporting Person hereto and is incorporated herein by reference for the Reporting Person. N Y Y Y Y Y Y Rainer M. Erdtmann /s/ Rainer M. Erdtmann 02/06/2026