SCHEDULE 13G/A 0001455767 XXXXXXXX LIVE 3 Common Stock, $0.0001 par value 06/30/2025 0001840439 Biomea Fusion, Inc. 09077A106 1599 Industrial Road San Carlos CA 94070 Rule 13d-1(d) Rainer M. Erdtmann b X1 2494434 480790 2494434 480790 2975224 N 5.2 IN Point Sur Investors, LLC b DE 480790 0 480790 0 480790 N 0.8 PN Point Sur Investors Fund I, L.P. b DE 228470 0 228470 0 228470 N 0.4 PN Biomea Fusion, Inc. 1599 Industrial Road, San Carlos, CA 94070 This statement is filed by the entities listed below, who are collectively referred to herein as "Reporting Persons," with respect to the shares of common stock of Biomea Fusion, Inc. (the "Company"), par value $0.0001 per share (the "Shares"). (i) Rainer M. Erdtmann, a citizen of the United States of America; (ii) Point Sur Investors, LLC, a Delaware limited liability company ("Point Sur LLC") ; and (iii) Point Sur Investors Fund I, L.P., a Delaware limited partnership ("Point Sur Investors Fund"). The address of the principal business office of Rainer M. Erdtmann is c/o Biomea Fusion, Inc., 1599 Industrial Road, San Carlos, CA 94070. The address of the principal business office of Point Sur LLC and Point Sur Investors Fund is 1073 Arlington Blvd., El Cerrito, CA 94530. See Item 2(a) above. N Rainer M. Erdtmann may be deemed to beneficially own 2,494,434 Shares, consisting of: (i) 482,404 Shares issuable upon the exercise of stock options exercisable within 60 days held directly by Rainer M. Erdtmann, (ii) 643,027 shares held directly by Rainer M. Erdtmann, (iii) an aggregate of 59,400 Shares held by the children of Rainer M. Erdtmann, (iv) 174,614 Shares held by a trust with an independent trustee ("Trust 1"); and (v) 1,134,989 Shares held by a separate trust with an independent trustee ("Trust 2"). Point Sur Investors Fund directly holds 228,470 Shares. Point Sur LLC directly holds 252,320 Shares. Point Sur LLC is the General Partner of Point Sur Investors Fund. Rainer M. Erdtmann is a managing member of Point Sur LLC and, as such, Mr. Erdtmann has shared voting and dispositive power over the Shares held by both Point Sur Investors Fund and Point Sur LLC. The percent of class of the outstanding Shares beneficially owned by the Reporting Persons in Item 4(a) are based on (i) 57,022,250 Shares outstanding as of the completion of the offering of the Shares referred to in the Company's Prospectus Supplement (to the Prospectus dated October 24, 2022, Registration No. 333-267884), filed on June 18, 2025 and (ii) 482,404 Shares issuable within 60 days after June 30, 2025 upon the exercise of options held directly by Rainer M. Erdtmann, which have been added to the Shares reported as outstanding in accordance with Rule 13d-3(d)(1)(i) under the Securities Exchange Act of 1934. The information required by this Item 4(c)(i) is set forth in Row 5 of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person. The information required by this Item 4(c)(ii) is set forth in Row 6 of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person. The information required by this Item 4(c)(iii) is set forth in Row 7 of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person. The information required by this Item 4(c)(iv) is set forth in Row 8 of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person. Y Y Y Y Y Y Rainer M. Erdtmann /s/ Rainer M. Erdtmann 08/13/2025 Point Sur Investors, LLC /s/ Rainer M. Erdtmann 08/13/2025 Point Sur Investors Fund I, L.P. /s/ Rainer M. Erdtmann 08/13/2025