SCHEDULE 13D/A 0000929638-23-001060 0001583977 XXXXXXXX LIVE 2 Common Stock 06/20/2025 false 0001840439 09077A106 Biomea Fusion, Inc.

900 MIDDLEFIELD ROAD 4TH FLOOR REDWOOD CITY CA 94063

Neb Obradovic 857-702-0386 Cormorant Asset Management, L.P. 200 Clarendon Street, 52nd Floor Boston MA 02116 0001618442 Cormorant Global Healthcare Master Fund, LP b WC E9 0 1795928 0 1795928 1795928 N 3.15 PN 0001618451 Cormorant Global Healthcare GP, LLC b AF DE 0 1795928 0 1795928 1795928 N 3.15 OO 0001817320 Cormorant Private Healthcare Fund III LP b WC DE 0 1717232 0 1717232 1717232 N 3.01 PN Y Cormorant Private Healthcare GP III, LLC b AF DE 0 1717232 0 1717232 1717232 N 3.01 OO 0001583977 Cormorant Asset Management, LP b AF DE 0 3570872 0 3570872 3570872 N 6.26 PN 0001599214 Chen Bihua b AF X1 110792 3570872 110792 3570872 3681664 N 6.46 IN Common Stock Biomea Fusion, Inc. 900 MIDDLEFIELD ROAD 4TH FLOOR REDWOOD CITY CA 94063 This Amendment No. 2 to Schedule 13D (this "Amendment") relates to Common Stock of Biomea Fusion, Inc., a Delaware corporation (the "Issuer" or the "Company"). The address of the principal executive offices of the Issuer is 900 Middlefield Road, 4th Floor, Redwood City, California 94063. This Amendment is being filed by the Reporting Persons to amend the Schedule 13D that was filed on April 30, 2021 and amended on April 3, 2023 (as amended, the "Schedule 13D"). Unless otherwise indicated, all capitalized terms used herein but not defined herein shall have the same meaning as in the Schedule 13D. Cormorant Global Healthcare Master Fund, LP Cormorant Global Healthcare GP, LLC Cormorant Private Healthcare Fund III, LP Cormorant Private Healthcare GP III, LLC Cormorant Asset Management, LP Bihua Chen 200 Clarendon Street, 52nd Floor Boston, MA 02116 Cormorant Global Healthcare Master Fund, LP - Cayman Islands Cormorant Global Healthcare GP, LLC - Delaware Cormorant Private Healthcare Fund III, LP - Delaware Cormorant Private Healthcare GP III, LLC - Delaware Cormorant Asset Management, LP - Delaware Bihua Chen - United States See Items 7-13 of the cover page and Item 2. See Items 7-13 of the cover page and Item 2. The percentages reported herein with respect to the Reporting Persons' holdings are calculated based upon (i) a statement in a Prospectus filed by the Issuer on June 18, 2025 that there would be 57,022,250 shares of Common Stock outstanding following the closing of a public offering described therein, and (ii) a statement in a Current Report on Form 8-K filed by the Issuer on June 20, 2025 announcing that the public offering closed on that date. The shares reported for Bihua Chen reflect shares of Common Stock that she has the right to receive within 60 days upon the exercise of stock options granted to her in her capacity as a director of the Issuer. The Reporting Persons did not engage in any transactions in securities of the Issuer during the sixty day period prior to the filing of this Schedule 13D. Not applicable. Not applicable. Cormorant Global Healthcare Master Fund, LP /s/ CORMORANT GLOBAL HEALTHCARE MASTER FUND, LP By: Cormorant Global Healthcare GP, LLC, its General Partner 07/22/2025 Cormorant Global Healthcare GP, LLC /s/ Bihua Chen 07/22/2025 Cormorant Private Healthcare Fund III LP /s/ CORMORANT PRIVATE HEALTHCARE FUND III, LP By: Cormorant Private Healthcare GP III, LLC, its General Partner 07/22/2025 Cormorant Private Healthcare GP III, LLC /s/ Bihua Chen 07/22/2025 Cormorant Asset Management, LP /s/ CORMORANT ASSET MANAGEMENT, LP By: Cormorant Asset Management GP, LLC, its General Partner 07/22/2025 Chen Bihua /s/ Bihua Chen 07/22/2025