X0306 4 2022-06-22 0 0001840439 Biomea Fusion, Inc. BMEA 0001572143 Faust Elizabeth C/O BIOMEA FUSION, INC. 900 MIDDLEFIELD ROAD, 4TH FLOOR REDWOOD CITY CA 94063 1 0 0 0 Stock Option (Right to Buy) 10.20 2022-06-22 4 A 0 45755 0.00 A 2032-06-21 Common Stock 45755 45755 D The shares underlying the stock option shall vest in 36 equal monthly installments over a three year period beginning on June 22, 2022, so that all shares shall have vested on June 22, 2025, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ Franco Valle as Attorney-in-Fact for Elizabeth Faust 2022-06-24