X0306 4 2022-05-31 0 0001840439 Biomea Fusion, Inc. BMEA 0001699848 Valle Franco C/O BIOMEA FUSION, INC. 900 MIDDLEFIELD ROAD, 4TH FLOOR REDWOOD CITY CA 94063 0 1 0 0 Chief Financial Officer Common Stock 2022-05-31 5 A 0 E 3307 4.6665 A 13307 D These shares were acquired under the Biomea Fusion, Inc. 2021 Employee Stock Purchase Plan ("ESPP") in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c). In accordance with the ESPP, these shares were purchased at a purchase price of 85% of the closing price of the Issuer's common stock on May 31, 2022. /s/ Franco Valle 2022-06-01