X0306 4 2022-01-14 0 0001840439 Biomea Fusion, Inc. BMEA 0001699848 Valle Franco C/O BIOMEA FUSION, INC. 900 MIDDLEFIELD ROAD, 4TH FLOOR REDWOOD CITY CA 94063 0 1 0 0 Chief Financial Officer Common Stock 2022-01-14 4 P 0 10000 8.6767 A 10000 D The price reported in Column 4 is a weighted-average price. These shares were purchased in multiple transactions at prices ranging from $8.5550 to $8.7400, inclusive. The reporting person undertakes to provide to Biomea Fusion, Inc., any security holder of Biomea Fusion, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in footnote 1 to this Form 4. Exhibit 24 - Power of Attorney /s/ Franco Valle 2022-01-18