X0306 4 2021-04-15 0 0001840439 Biomea Fusion, Inc. BMEA 0001262325 AGUIAR ERIC C/O BIOMEA FUSION, INC. 726 MAIN ST REDWOOD CITY CA 94063 1 0 0 0 Stock Option (Right to Buy) 17.00 2021-04-15 4 A 0 28911 0.00 A 2031-04-14 Common Stock 28911 28911 D The shares underlying the stock option vest in equal monthly installments over a three year period beginning on April 20, 2021, so that all shares shall have vested on April 20, 2024, subject to the Reporting Person continued service to the Issuer through each vesting date. /s/ Sunny Lee Ryan, as Attorney-in-fact for Eric Aguiar 2021-04-19