Collaboration and License Agreements - Gilead Sciences, Inc. (Details) $ / shares in Units, $ in Thousands	1 Months Ended			12 Months Ended
	Dec. 31, 2024 USD ($) $ / shares shares	Apr. 30, 2024 USD ($) $ / shares shares	Mar. 31, 2024 USD ($) item $ / shares shares	Dec. 31, 2024 USD ($) $ / shares	Dec. 31, 2023 USD ($)
Agreements
Revenue				$ 6,344
Revenue from Contract with Customer, Product and Service				us-gaap:LicenseMember	us-gaap:LicenseMember
Deferred revenue, current portion	$ 13,518			$ 13,518
License and Stock Purchase Agreement | Gilead Sciences, Inc.
Agreements
Maximum additional contingent payments receivable, Transition fee			$ 75,000	$ 75,000
Value of shares counterparty agreed to purchase			$ 25,000
Number of additional private placements | item			3
Maximum beneficial ownership (as a percent)		19.90%
Common stock issued and sold (in shares) | shares	1,759,978	485,250	6,860,223
Purchase price (in dollars per share) | $ / shares	$ 1.04	$ 0.76	$ 1.97	$ 1.04
Gross proceeds from private placement	$ 8,200	$ 3,300	$ 13,500	$ 25,000
Upfront payment				55,000
Upfront payment, cash				30,000
Maximum additional contingent payments receivable				592,500
Maximum additional contingent payments receivable, Milestones				517,500
Maximum additional contingent payments receivable, Near-term development milestones				17,500
Fair market value of common stock issued (in dollars)			4,400
Premium of common stock issued (in dollars)			9,100
Transaction price			39,100
Transaction price, Cash payment			30,000
Transaction price, Premium on sale of stock			$ 9,100
Revenue				$ 6,300
Revenue from Contract with Customer, Product and Service				us-gaap:LicenseMember
Deferred revenue	32,780			$ 32,780
Current liability	$ 13,500			$ 13,500
License and Stock Purchase Agreement | Gilead Sciences, Inc. | Prefunded warrants
Agreements
Warrants issued (in shares) | shares	6,092,816	3,882,450
Purchase price, warrant (in dollars per share) | $ / shares	$ 1.0399	$ 0.7599		$ 1.0399
Exercise price, warrants (in dollars per share) | $ / shares	$ 0.0001	$ 0.0001		$ 0.0001