X0202 SCHEDULE 13G 0001930149 XXXXXXXX LIVE Common Stock, par value $0.0001 per share 08/10/2026 0001839970 BlossomHill Therapeutics, Inc. 095130100 10255 Science Center Drive Suite 200 San Diego CA 92121 Rule 13d-1(c) Vivo Innovation Fund II Holdings, L.P. b DE 1681240.00 0.00 1681240.00 0.00 1681240.00 N 5.5 PN The number represents shares of common stock, par value $0.0001 per share (the "Common Stock") of BlossomHill Therapeutics, Inc. (the "Issuer"), which are held of record by Vivo Innovation Fund II Holdings, L.P. Vivo Innovation II, LLC is the general partner of Vivo Innovation Fund II Holdings, L.P. The percent is based on 30,643,660 shares of the Issuer's Common Stock outstanding (excluding the full exercise of the underwriters' over-allotment option) after the completion of the initial public offering, as reported in the Issuer's prospectus filed with the Securities and Exchange Commission (the "SEC") on August 7, 2026, pursuant to Rule 424(b)(4), which forms part of the Issuer's Registration Statement on Form S-1 (File No. 333-297512). Vivo Innovation II, LLC b DE 1681240.00 0.00 1681240.00 0.00 1681240.00 N 5.5 OO The number represents shares of Common Stock of the Issuer, which are held of record by Vivo Innovation Fund II Holdings, L.P. Vivo Innovation II, LLC is the general partner of Vivo Innovation Fund II Holdings, L.P. The percent is based on 30,643,660 shares of the Issuer's Common Stock outstanding (excluding the full exercise of the underwriters' over-allotment option) after the completion of the initial public offering, as reported in the Issuer's prospectus filed with the SEC on August 7, 2026, pursuant to Rule 424(b)(4), which forms part of the Issuer's Registration Statement on Form S-1 (File No. 333-297512). BlossomHill Therapeutics, Inc. 10255 Science Center Drive, Suite 200, San Diego, California 92121 Vivo Innovation Fund II Holdings, L.P. and its General Partner Vivo Innovation II, LLC 192 Lytton Avenue, Palo Alto, CA 94301 Vivo Innovation Fund II Holdings, L.P. is a Delaware limited partnership. Vivo Innovation II, LLC is a Delaware limited liability company. Y 1,681,240 shares of the Issuer's Common Stock are held of record by Vivo Innovation Fund II Holdings, L.P. Vivo Innovation II, LLC is the general partner of Vivo Innovation Fund II Holdings, L.P. Vivo Innovation Fund II Holdings, L.P.: 5.5% Vivo Innovation II, LLC: 5.5% Vivo Innovation Fund II Holdings, L.P.: 1,681,240 shares Vivo Innovation II, LLC: 1,681,240 shares 0 Vivo Innovation Fund II Holdings, L.P.: 1,681,240 shares Vivo Innovation II, LLC: 1,681,240 shares 0 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. 99.1 Joint Filing Statement Vivo Innovation Fund II Holdings, L.P. /s/ Gaurav Aggarwal 08/17/2026 Vivo Innovation II, LLC /s/ Gaurav Aggarwal 08/17/2026