X0206 3 2020-12-27 0 0000874015 IONIS PHARMACEUTICALS INC IONS 0001838539 Schneider Eugene C/O IONIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD, CA 92010 0 1 0 0 EVP, Chf Clinical Develop Offc Common Stock 2118 D Employee Stock Option (right to buy) 61.57 2022-01-01 Common Stock 6100.0 D Employee Stock Option (right to buy) 63.18 2022-03-31 Common Stock 18750 D Employee Stock Option (right to buy) 61.68 2023-01-03 Common Stock 11000.0 D Employee Stock Option (right to buy) 47.34 2024-01-02 Common Stock 25000 D Employee Stock Option (right to buy) 49.25 2025-01-01 Common Stock 25000 D Employee Stock Option (right to buy) 45.04 2025-07-28 Common Stock 7500 D Employee Stock Option (right to buy) 53.77 2026-01-01 Common Stock 19658 D Employee Stock Option (right to buy) 60.89 2027-01-01 Common Stock 26000 D Restricted Stock Units Common Stock 1041.0 D Restricted Stock Units Common Stock 2777 D Restricted Stock Units Common Stock 833.0 D Restricted Stock Units Common Stock 6552 D Restricted Stock Units Common Stock 11556 D Grant on 01/02/2015 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. 25% of the shares subject to the option vested and became exercisable on 1/02/2016. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments. The option is exercisable as to 6,100 shares on 12/27/2020 Grant on 04/01/2015 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. 25% of the shares subject to the option vested and became exercisable on 04/01/2016. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments. The option is exercisable as to 18,750 shares on 12/27/2020 Grant on 01/04/2016 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. 25% of the shares subject to the option vested and became exercisable on 1/4/2017. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments. The option is exercisable as to 11,000 shares on 12/27/2020 Grant on 01/03/2017 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. 25% of the shares subject to the option vested and became exercisable on 1/03/2018. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments. The option is exercisable as to 24,479 shares on 12/27/2020 Grant on 01/02/2018 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. 25% of the shares subject to the option vested and became exercisable on 1/02/2019. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments. The option is exercisable as to 18,229 shares on 12/27/2020 Grant on 07/29/2018 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. 25% of the shares subject to the option vested and became exercisable on 07/29/2019. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments. The option is exercisable as to 4,375 shares on 12/27/2020 Grant on 01/02/2019 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. 25% of the shares subject to the option vested and became exercisable on 01/02/2020. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments. The option is exercisable as to 9,420 shares on 12/27/2020 Grant on 01/02/2020 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. Amended and Restated 2011 Equity Incentive Plan. 25% of the shares subject to the option will be vested and become exercisable on 01/02/2021. Thereafter, the remaining shares subject to the option vested and became exercisable in 36 equal monthly installments. The option is exercisable as to 0 shares on 12/27/2020 The restricted stock units vest in four equal annual installments, the first installment vesting was on January 15, 2018. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2021. The restricted stock units vest in four equal annual installments, the first installment vesting was on January 15, 2019. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2022. The restricted stock units vest in four equal annual installments, the first installment vesting was on October 15, 2019. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on October 15, 2022. The restricted stock units vest in four equal annual installments, the first installment vesting was on January 15,2020. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2023. The restricted stock units vest in four equal annual installments, the first installment vesting on January 15, 2021. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on January 15, 2024. Each restricted stock unit represents a contingent right to receive one share of Ionis common stock or its equivalent cash value /s/Patrick R. O'Neil, attorney-in-fact 2021-01-06