September 27, 2022

Via EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attn:    Jane Park

Re:    VectivBio Holding AG

    Acceleration Request for Registration Statement on Form F-3

    File No. 333-265546

Ladies and Gentlemen:

The undersigned registrant hereby respectfully advises the staff (the “Staff”) of the U.S. Securities and Exchange Commission that it is withdrawing its previous request that the above-referenced Registration Statement be declared effective on Monday, September 26, 2022. The registrant hereby undertakes to advise the Staff regarding any future acceleration request as soon as possible.

[Signature page follows]

Very truly yours,

VectivBio Holding AG

By: /s/ Claudia D’ Augusta

Claudia D’Augusta

Chief Financial Officer

cc:    Scott Applebaum, VectivBio Holding AG

Brandon Fenn, Cooley LLP

    Dayne Brown, Cooley LLP

Andreas Müller, Homburger AG