X0306 4 2022-03-01 0 0000873303 Sarepta Therapeutics, Inc. SRPT 0001836218 Rodino-Klapac Louise 215 FIRST STREET CAMBRIDGE MA 0 1 0 0 Head of R&D, CSO Common Stock 2022-03-01 4 F 0 572 75.05 D 65327 D Shares were withheld by the Company to satisfy tax withholding obligations related to vesting of restricted stock units granted on February 28, 2020. The amount of securities directly owned by the reporting person includes 221 shares of common stock purchased under the Company's Amended and Restated 2013 Employee Stock Purchase Plan on February 28, 2022. /s/ Ryan Brown, as Attorney-in-Fact for Louise Rodino-Klapac 2022-03-01