X0306 4 2021-11-16 0 0000873303 Sarepta Therapeutics, Inc. SRPT 0001836218 Rodino-Klapac Louise 215 FIRST STREET CAMBRIDGE MA 0 1 0 0 Chief Scientific Officer Common Stock 2021-11-16 4 A 0 40000 0.00 A 61898 D The Reporting Person was granted restricted stock units ("RSUs"). Each RSU represents the right to receive one share of common stock. 25% of the shares of common stock underlying each RSU will vest on the first anniversary of the grant date, and additional 25% will vest on each anniversary of the Grant Date thereafter, such that the RSUs will be fully vested on the fourth anniversary of the grant date. The amount of securities directly owned by the reporting person includes 118 shares of common stock purchased under the Company's Amended and Restated 2013 Employee Stock Purchase Plan on August 31, 2021. /s/ Ryan Brown, as Attorney-in-Fact for Louise Rodino-Klapac 2021-11-17