Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule Of Loss Before Income Tax

Loss before income taxes was as follows for the years ended December 31, (in thousands):

	2022			2021
U.S. operations	$	(73,132	)	$	(61,541	)
Non-U.S. operations		(2,927	)		(6,746	)
Loss before provision for income taxes	$	(76,059	)	$	(68,287	)

Schedule of Components of Income Tax Expense (Benefit)

The components of the provision for income taxes was as follows for the years ended December 31, (in thousands):

	2022		2021
Current:
U.S.	$	—	$	—
State and local		1		1
Foreign		1,936		—
Total current		1,937		1
Deferred:
U.S.		—		—
Total deferred		—		—
Total provision for income taxes	$	1,937	$	1

Schedule of Effective Income Tax Rate Reconciliation

reconciliation of the Company’s statutory income tax rate to the Company’s effective income tax rate for the years ended December 31, was as follows:

	2022			2021
Income tax benefit at Cayman statutory rate		0.00	%		0.00	%
U.S. and non-U.S. rate differential		21.57	%		19.49	%
State taxes		4.77	%		3.94	%
R&D credits		0.73	%		3.00	%
Change in valuation allowance		(27.61	%)		(25.79	%)
Share-based compensation		(3.62	%)		(0.66	%)
Ambrx Shanghai reorganization		1.77	%		0.00	%
Other, net		(0.16	%)		0.02	%
Effective tax rate		(2.55	%)		(0.00	%)

Schedule of Deferred Tax Assets and Liabilities

Significant components of the Company’s deferred tax assets as of December 31, are shown below (in thousands):

	2022			2021
Deferred tax assets:
Net operating loss carryforwards	$	57,647		$	48,179
R&D credits		16,385			14,317
Capitalized R&D		8,980			—
Lease liabilities		3,110			3,662
Share-based compensation		1,219			3,223
Deferred revenues		454			1,575
Intangible assets		337			—
Other		945			1,047
Total deferred tax assets		89,077			72,003
Deferred tax liabilities:
IPR&D		(5,436	)		(5,841	)
Right-of-use assets		(2,847	)		(3,553	)
Intangible assets		—			(2,445	)
Total deferred tax liabilities		(8,283	)		(11,839	)
Net deferred tax assets		80,794			60,164
Less: valuation allowance		(81,674	)		(61,044	)
	$	(880	)	$	(880	)

Schedule of Unrecognized Tax Benefits

A reconciliation of the beginning and ending amount of unrecognized tax benefits was as follows (in thousands):

	December 31,
	2022		2021
Beginning balance	$	2,767	$	2,282
Additions based on tax positions related to the current year		1,958		485
Ending balance	$	4,725	$	2,767