75000 - Document - Document and Entity Information
link:presentationLink
link:calculationLink
link:definitionLink
75010 - Statement - CONSOLIDATED BALANCE SHEETS
link:presentationLink
link:calculationLink
link:definitionLink
75020 - Statement - CONSOLIDATED BALANCE SHEETS (PARENTHETICAL)
link:presentationLink
link:calculationLink
link:definitionLink
75030 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
link:presentationLink
link:calculationLink
link:definitionLink
75040 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY
link:presentationLink
link:calculationLink
link:definitionLink
75050 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (PARENTHETICAL)
link:presentationLink
link:calculationLink
link:definitionLink
75060 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS
link:presentationLink
link:calculationLink
link:definitionLink
75070 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS 2
link:presentationLink
link:calculationLink
link:definitionLink
995455 - Disclosure - Cybersecurity Risk Management, Strategy, and Governance
link:presentationLink
link:calculationLink
link:definitionLink
995465 - Disclosure - Nature of Business
link:presentationLink
link:calculationLink
link:definitionLink
995475 - Disclosure - Summary of Significant Accounting Policies
link:presentationLink
link:calculationLink
link:definitionLink
995485 - Disclosure - Fair Value Measurements
link:presentationLink
link:calculationLink
link:definitionLink
995495 - Disclosure - Property and Equipment, Net
link:presentationLink
link:calculationLink
link:definitionLink
995505 - Disclosure - Accrued Expenses
link:presentationLink
link:calculationLink
link:definitionLink
995515 - Disclosure - Leases
link:presentationLink
link:calculationLink
link:definitionLink
995525 - Disclosure - Related Party Transactions
link:presentationLink
link:calculationLink
link:definitionLink
995535 - Disclosure - Commitments and Contingencies
link:presentationLink
link:calculationLink
link:definitionLink
995545 - Disclosure - Stockholders' Equity
link:presentationLink
link:calculationLink
link:definitionLink
995555 - Disclosure - Stock-Based Compensation
link:presentationLink
link:calculationLink
link:definitionLink
995565 - Disclosure - Income Taxes
link:presentationLink
link:calculationLink
link:definitionLink
995575 - Disclosure - Segment Reporting
link:presentationLink
link:calculationLink
link:definitionLink
995585 - Disclosure - Retirement Plan
link:presentationLink
link:calculationLink
link:definitionLink
995595 - Disclosure - Summary of Significant Accounting Policies (Policies)
link:presentationLink
link:calculationLink
link:definitionLink
995605 - Disclosure - Summary of Significant Accounting Policies (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995615 - Disclosure - Fair Value Measurements (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995625 - Disclosure - Property and Equipment, Net (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995635 - Disclosure - Accrued Expenses (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995645 - Disclosure - Leases (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995655 - Disclosure - Stockholders' Equity (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995665 - Disclosure - Stock-Based Compensation (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995675 - Disclosure - Income Taxes (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995685 - Disclosure - Segment Reporting (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
995695 - Disclosure - Nature of Business - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995705 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995715 - Disclosure - Summary of Significant Accounting Policies - Summary of Estimated Useful Lives of Property and Equipment (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995725 - Disclosure - Summary of Significant Accounting Policies - Summary of Outstanding Potentially Dilutive Securities Excluded in Calculation of Diluted Net Loss per Share (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995735 - Disclosure - Fair Value Measurements - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995745 - Disclosure - Fair Value Measurements - Summary of Marketable Securities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995755 - Disclosure - Fair Value Measurements - Summary of Fair Value of Financial Assets Measured at Fair Value on Recurring Basis (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995765 - Disclosure - Fair Value Measurements - Summary of Reconciliation of Warrant Liabilities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995775 - Disclosure - Fair Value Measurements - Summary of Maturity of Company's Marketable Securities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995785 - Disclosure - Property and Equipment, Net - Summary of Cost and Accumulated Depreciation of Property and Equipment (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995795 - Disclosure - Property and Equipment, Net - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995805 - Disclosure - Accrued Expenses - Schedule of Accrued Expenses (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995815 - Disclosure - Leases - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995825 - Disclosure - Leases - Summary of Components of Lease Cost (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995835 - Disclosure - Leases - Summary of Supplemental Disclosure of Cash Flow Information Related to Leases (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995845 - Disclosure - Leases - Schedule of Future Minimum Lease Payments under Non-Cancelable Operating Leases (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995855 - Disclosure - Leases - Schedule of Future Minimum Lease Payments under Non-Cancelable Operating Leases (Details) 2
link:presentationLink
link:calculationLink
link:definitionLink
995865 - Disclosure - Related Party Transactions - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995875 - Disclosure - Stockholders' Equity - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995885 - Disclosure - Stockholders' Equity - Schedule of Reserved Shares of Common Stock for Issuance, on an As-Converted Basis (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995895 - Disclosure - Stock-Based Compensation - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995905 - Disclosure - Stock-Based Compensation - Schedule of Weighted Average Assumptions Used to Compute Estimated Fair Value of Stock Options Granted (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995915 - Disclosure - Stock-Based Compensation - Summary of Stock Options Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995925 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Units (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995935 - Disclosure - Stock-Based Compensation - Summary of Stock-based Compensation Expense (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995945 - Disclosure - Income Taxes - Schedule of Loss Before for Income Taxes (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995955 - Disclosure - Income Taxes - Components of Net Deferred Income Taxes (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995965 - Disclosure - Income Taxes - Schedule of Components of Income Tax Expense (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995975 - Disclosure - Income Taxes - Reconciliation of Income Tax Expense to Statutory Federal Income Tax Rate to Loss from Operations (Details)
link:presentationLink
link:calculationLink
link:definitionLink
995985 - Disclosure - Income Taxes - Reconciliation of Income Tax Expense to Statutory Federal Income Tax Rate to Loss from Operations (Details) 2
link:presentationLink
link:calculationLink
link:definitionLink
995995 - Disclosure - Income Taxes - Summary of Income Taxes Paid by Jurisdiction (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996005 - Disclosure - Income Taxes - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996015 - Disclosure - Income Taxes - Reconciliation of Unrecognized Tax Benefits Recorded in Statement of Operations (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996025 - Disclosure - Segment Reporting - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996035 - Disclosure - Segment Reporting - Schedule of Functional Operating Expenses (Details)
link:presentationLink
link:calculationLink
link:definitionLink
996045 - Disclosure - Retirement Plan - Additional Information (Details)
link:presentationLink
link:calculationLink
link:definitionLink
Measurement date fair value of shares vested per share
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Weighted-Average Grant Date Fair Value, Vested
Segments [Domain]
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Foreign
Number of shares outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding, Number
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding, Number, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding, Number, Beginning Balance
Deferred Tax Assets, Gross [Abstract]
Deferred tax assets:
Entity Incorporation, State or Country Code
Statement of Financial Position Location, Balance [Domain]
Beginning balance
Ending balance
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Supplemental noncash investing and financing activities
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One
Maturing in one year or less
Plan Name [Axis]
Research and Development Expenses
Research and Development Expense [Abstract]
Equity [Abstract]
Entity Current Reporting Status
Proceeds from warrant exercises
Proceeds from Warrant Exercises
Proceeds from issuance of common stock upon exercise of Series A-2 warrants
Operating Expenses [Abstract]
Operating expenses:
Level 2
Fair Value, Inputs, Level 2 [Member]
Deferred Tax Assets, Net of Valuation Allowance
Net deferred tax assets
Net deferred tax assets
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Common stock, shares authorized
Common Stock, Shares Authorized
Temporary Equity, Par or Stated Value Per Share
Temporary equity, par value
Price per share
Facility Related and Other [Member]
Facility related and other.
Facility Related and Other
Product and Service [Axis]
Document Fiscal Period Focus
Accounting Standards Update 2023-09 [Member]
ASU 2023-09
Entity Shell Company
Other
Other Accrued Liabilities, Current
Cash dividend
Dividends, Common Stock, Cash
Segment Reporting, Policy [Policy Text Block]
Segment Reporting
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalent
Subsidiary, Sale of Stock [Line Items]
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common Stock, Shares, Issued
Common stock, shares, issued
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Lessee, Operating Lease, Description
Lease, description
Statement [Table]
Series A-2 Preferred Stock Warrant Liability
Series A-2 Preferred Stock Warrant Liability [Member]
Series A-2 Preferred Stock Warrant Liability.
Restricted cash
Restricted Cash, Noncurrent
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Increase related to current year tax positions
Internal Revenue Service (IRS) [Member]
Internal Revenue Service (IRS)
Weighted average grant date fair value of stock options granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Harrison lease.
Harrison Lease [Member]
Harrison Lease
Statement [Line Items]
Entity Filer Category
Total liabilities, convertible preferred stock, and stockholders' deficit
Liabilities and Equity
Total liabilities and stockholders' equity
Purchases of marketable securities
Payments to Acquire Marketable Securities
Long-Lived Tangible Asset [Axis]
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent, Total
Cumulative translation adjustment arising during the period
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent
Operating Loss Carryforwards [Table]
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Lessee, Operating Lease, Option to Terminate
Lease termination term
Cash Equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
U.S. Federal Statutory Tax Rate
Statutory federal income tax rate
Public offering price per share
Shares Issued, Price Per Share
Computer and Office Equipment
Computer And Office Equipment Member
Computer and office equipment member.
Nontaxable or Nondeductible Items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount, Total
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Effective Income Tax Rate Reconciliation, Percent
Income tax expense (benefit)
Stock Options
Interest income
Investment Income, Interest
Income Tax Jurisdiction [Axis]
Geographical [Domain]
Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Percentage of participating employees eligible earnings
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Additional paid-in capital
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock, Ending Balance
Additional Paid in Capital, Common Stock
At The Market Issuance Sales Agreement [Member]
At the market issuance sales agreement.
At-the-Market Equity Offering Sales Agreement
Defined Contribution Plan [Text Block]
Retirement Plan
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Property, Plant and Equipment [Line Items]
Option to purchase
Stock Options, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Required to pay exit fee amount
Required to Pay Exit Fee Amount
Required to pay exit fee amount.
Cybersecurity Risk Management, Strategy, and Governance [Table]
Other receivables
Increase (Decrease) in Other Receivables
Investment, Name [Axis]
Investments Classified by Contractual Maturity Date [Table Text Block]
Summary Of Maturity Of Company's Marketable Securities
Earnings Per Share, Basic, Total
Net loss per share, basic
Earnings Per Share, Basic
Carnot Pharma, LLC
Carnot Pharma, LLC [Member]
Carnot Pharma, LLC.
Foreign currency translation adjustment
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Total
Cumulative translation adjustment arising during the period
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Outstanding vested and unvested stock options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Stock Options Outstanding as of December 31, 2024
Stock Options, Outstanding as of December 31, 2025
Total current liabilities
Total current liabilities
Liabilities, Current
Unrecognized tax benefits, income tax penalties
Unrecognized Tax Benefits, Income Tax Penalties Expense
Adjustments to reconcile net loss to cash used in operating activities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Lessee, Operating Lease, Liability, to be Paid, Year Five
2030
Percentage of exit fee
Percentage Of Exit Fee
Percentage of exit fee.
Summary of Reconciliation of Warrant Liabilities
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Domestic Tax Jurisdiction [Member]
Federal
United States - Federal
Taxes on Interest Income Generated from Cash Equivalents and Marketable Securities
Taxes on interest income generated from cash equivalents and marketable securities.
Taxes on interest income generated from cash equivalents and marketable securities
Tenant Improvement
Tenant Improvement [Member]
Tenant improvement member.
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Increase related to prior year tax positions
Accounting Standards Update [Axis]
Percentage of corporation taxable income for limit on net operating losses deduction
Percentage of Corporation Taxable Income for Limit on Net Operating Losses Deduction
Percentage of corporation taxable income for limit on net operating losses deduction.
Undesignated Preferred Stock
Undesignated Preferred Stock [Member]
Undesignated referred stock.
Stockholders' equity:
Equity, Attributable to Parent [Abstract]
Entity Small Business
Increase (Decrease) in Accrued Liabilities, Total
Increase (Decrease) in Accrued Liabilities
Accrued expenses and other non-current liabilities
Leased space
Leased Space
Leased space
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit)
Stock compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Accounting Standards Update 2016-02 [Member]
ASU 2016-02
Nature of Operations [Text Block]
Nature of Business
Stock Issued During Period Shares Vesting Of Restricted Stock And Performance Stock Units
Stock issued during period shares vesting of restricted stock and performance stock units
Vesting of restricted stock and performance stock units, Shares
Subsidiary or Equity Method Investee, Sale of Stock, Type [Table]
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Amount, Total
Effect of Cross-Border Tax Laws
Entity Well-known Seasoned Issuer
Stock Options, Canceled/Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Gross proceeds from sale of shares
Proceeds from Issuance Initial Public Offering
Issuance of common stock in public offering, net of underwriters' fees
Intrinsic value of stock options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Current Foreign Tax Expense (Benefit)
Foreign
Expected dividend yield
Warrants and Rights Outstanding, Measurement Input
Aggregate operating lease cost.
Total payments to the landlord for improvements
Aggregate Operating Lease cost
Share-Based Payment Arrangement [Text Block]
Stock-Based Compensation
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Defined Contribution Plan [Table]
Lease Contractual Term [Axis]
Leases [Abstract]
Class A Common Stock
Common Class A [Member]
Commitments and contingencies [Line Items]
Lessee, Lease, Description [Line Items]
Amendment Flag
Amendment
Product and Service [Domain]
U.S. Federal Statutory Tax Rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Warrants exercised, date
Class of Warrant or Right, Date from which Warrants or Rights Exercisable
Preferred stock warrants exercised
Number of warrants purchase granted
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Liabilities and Equity [Abstract]
Liabilities and stockholders' equity
Entity Address, Postal Zip Code
Net cash used in operating activities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Increase (Decrease) in Operating Lease Liability
Operating lease liabilities, current and non-current
Common Stock
Common stock
Common Stock [Member]
Accounting Standards Update and Change in Accounting Principle [Table]
Cybersecurity Risk Role of Management [Text Block]
Unrecognized Tax Benefits, Decrease Resulting from Foreign Currency Translation
Currency translation
Currency translation
Contribution expense related to match
Defined Contribution Plan, Employer Discretionary Contribution Amount
Weighted Average Exercise Price, Granted
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Lessee, Operating Lease, Liability, to be Paid, Year Three
2028
Less: accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Income Tax Paid, by Individual Jurisdiction [Line Items]
Entity Address, Address Line One
Deferred Tax Liabilities, Gross
Deferred tax liabilities
Deferred tax liabilities
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of Weighted Average Assumptions Used to Compute Estimated Fair Value of Stock Options Granted
Fair Value Hierarchy and NAV [Axis]
Income Taxes
Income Tax, Policy [Policy Text Block]
Convertible preferred stock
Temporary Equity Beginning Balance
Temporary Equity Ending Balance
Temporary Equity, Carrying Amount, Attributable to Parent
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Foreign Currency Remeasurement
Statement of Financial Position Location, Balance [Axis]
Schedule of estimated useful lives of property and equipment.
Summary of Estimated Useful Lives of Property and Equipment
Right-of-use assets
Operating Lease, Right-of-Use Asset
Operating lease right-of-use asset
Deferred Tax Assets, Gross
Deferred tax assets
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax, Total
Unrealized (loss) gain on marketable securities
Document Type
Document Type
Cash paid for taxes
Income Taxes Paid, Net
Income Taxes Paid, Net, Total
Income tax expense (benefit)
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
CIK
Entity Central Index Key
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Net increase (decrease) in cash, cash equivalents and restricted cash
Subsequent Event Type [Domain]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Impairment of Long-Lived Assets to be Disposed of
Impairments of long-lived assets
Impairment of long-lived assets
Common Stock, Par or Stated Value Per Share
Common stock, par value
Accounting Standards Update [Domain]
General business credits
Deferred Tax Assets, Tax Credit Carryforwards, General Business
Operating lease period of extension.
Operating Lease Period Of Extension
Additional period of lease
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Outstanding, Weighted Average Remaining Life
Amortized Cost
Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Defined Contribution Plan Disclosure [Line Items]
Components of Deferred Tax Assets and Liabilities [Abstract]
Total
Total
Debt Securities, Available-for-Sale
Class A and Class B Common Stock
Class A and Class B Common Stock [Member]
Class A and Class B common stock.
Document Financial Statement Error Correction [Flag]
Common stock issued in connection with exercise of stock options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Stock Options, Exercised
Exercise of stock options, Shares
Changes in ownership by stockholders holding percentage.
Changes In Ownership By Stockholders Holding Percentage
Changes in ownership by stockholders holding percentage
Total accrued expenses
Accrued expenses
Accrued Liabilities, Current
Summary of Income Taxes Paid by Jurisdiction
Schedule of Components of Income Tax Paid By Jurisdiction [Table Text Block]
Schedule of components of income tax paid by jurisdiction.
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Current Fiscal Year End Date
Fair Value, by Balance Sheet Grouping [Table]
Entity Address, State or Province
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Number of Shares, Issued and unvested
Outstanding as of December 31, 2024
Outstanding as of December 31, 2025
Number of shares outstanding
Term of license agreement
Term of License Agreement
Term of license agreement.
Other General and Administrative
Other General and Administrative Expenses [Member]
Other general and administrative expenses.
Investment, Name [Domain]
Leases disclosure.
Leases Disclosure [Text Block]
Leases
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Research and Development Expense, Policy [Policy Text Block]
Research and Development
Reserved shares of common stock for issuance
Initially common stock reserved for future issuance
Common Stock, Capital Shares Reserved for Future Issuance
Geographical [Axis]
Net loss per share.
Net Loss Per Share [Policy Text Block]
Net loss per share
Marketable Securities, Current
Marketable securities
State and Local Income Tax, Net of Federal (National) Income Tax Effect
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount
Summary of Stock-based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Stock Issued During Period, Value, Stock Options Exercised
Exercise of stock options
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Components of Net Deferred Income Taxes
PSUs
Performance Shares [Member]
Subsequent Event
Subsequent Event [Member]
Marketable Securities
Marketable Securities, Policy [Policy Text Block]
Property, Plant and Equipment [Abstract]
Deferred Tax Assets, Tax Credit Carryforwards, Research
Research and development credits
Other Assets, Noncurrent, Total
Other assets
Other Assets, Noncurrent
Gross proceeds from issuance of convertible preferred stock
Proceeds from issuance of convertible preferred stock, net of issuance costs
Proceeds from Issuance of Convertible Preferred Stock
Antidilutive Securities [Axis]
Income Taxes [Line Items]
Operating Loss Carryforwards [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Award vesting percentage
Measurement date aggregate fair value of shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Vested and expected to vest, Aggregate Intrinsic Value
Patent Procurement Milestone Payments
Patent procurement milestone payments.
Patent procurement milestone payments
Commission to sales agent for gross proceeds from sales
Percentage Of Commission To Sales Agent From Sales
Percentage of commission to sales agent from sales.
State and Local Jurisdiction [Member]
State
United States - State and local
Related Party Transaction [Axis]
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Income (Loss)
Accumulated Other Comprehensive Income
Noncash Merger Related Costs
Other non-cash adjustments
Additional payments of restatement completion fee and license data fee
Additional Payments of Restatement Completion Fee and License Data Fee
Additional payments of restatement completion fee and license data fee.
Operating lease monthly rent expense.
Operating Lease Monthly Rent Expense
Monthly rent expense
Lessee, Operating Lease, Option to Extend
Option to extend lease
Preferred Stock, Value, Issued
Preferred stock, $0.0001 par value; 10,000,000 shares authorized at December 31, 2024 and 2023, respectively
Preferred stock, $0.0001 par value; 10,000,000 shares authorized at December 31, 2025 and 2024, respectively
Minimum
Minimum [Member]
Weighted-Average Grant Date Fair Value, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant date fair value, granted
Financial Instrument [Axis]
Current assets:
Assets, Current [Abstract]
Level 3
Fair Value, Inputs, Level 3 [Member]
Accrued Expenses
Accrued liabilities Current Disclosure [Text Block]
Accrued liabilities current disclosure.
Segment Reporting [Abstract]
Deferred Tax Liabilities, Property, Plant and Equipment
Fixed Assets
Fixed Assets
Operating loss carry forwards, expiration year.
Operating Loss Carry forwards Expiration Year
Operating loss carry forwards expiration year
Summary of Fair Value of Financial Assets Measured at Fair Value on Recurring Basis
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Current liabilities:
Liabilities, Current [Abstract]
Stock Restriction Agreements
Stock Restriction Agreements [Member]
Stock Restriction Agreements [Member]
UK tax authorities.
UK Tax Authorities [Member]
UK Tax Authorities
Related Party Transactions [Abstract]
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities
Accrued expenses
Shares, Outstanding
Ending Balance, Shares
Beginning Balance, Shares
Operating Loss Carryforwards
Net operating losses
Income Tax Paid, by Individual Jurisdiction [Abstract]
Restricted Cash and Cash Equivalents, Total
Cash
Restricted Cash and Cash Equivalent
Proceeds from employee equity plans
Proceeds from Stock Plans
Stock Purchase Agreement
Stock Purchase Agreement [Member]
Stock purchase agreement.
Lessee, Leases [Policy Text Block]
Leases
Weighted-Average Grant Date Fair Value, Issued and unvested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Issued and unvested
Weighted Average Grant Date Fair Value, Issued and unvested
General and Administrative Expense [Member]
General and Administrative
Technology License Agreement
Technology License Agreement [Member]
Technology license agreement.
Operating lease liability
Lease liabilities
Operating Lease, Liability
Present value of lease liability
Auditor Firm ID
Reverse stock split, description
Stockholders' Equity, Reverse Stock Split
Prepaids and other current and non-current assets
Increase (Decrease) in Prepaid Expenses, Other
Lessee, Lease, Description [Table]
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Payment of offering costs
Payment of Offering Costs
Payment of offering costs.
Offering expenses
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Amortization of premium and discounts on marketable securities, net
Amortization Of Premium And Discounts On Marketable Securities Net
Amortization of premium and discounts on marketable securities, net.
Lease Contractual Term [Domain]
Income Tax Examination, Penalties and Interest Accrued
Accrual for interest or penalties
Accrual for interest or penalties
Number of founding stockholders entered
Number of Founding Stockholders Entered
Number of founding stockholders entered.
Percentage of repurchase rights lapse on second anniversary
Percentage of Repurchase Rights Lapse on Second Anniversary
Percentage of repurchase rights lapse on second anniversary.
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted-average common shares outstanding, basic
Weighted Average Number of Shares Outstanding, Basic
Series A-2 Convertible Preferred Stock
Series A-2 Convertible Preferred Stock [Member]
Series A-2 convertible preferred stock.
Emerging growth company status.
Emerging Growth Company Status [Policy Text Block]
Emerging Growth Company Status
Temporary Equity [Abstract]
Convertible preferred stock:
Segment Reporting, Expense Information Used by CODM, Description
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Amount
Other
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Reconciliation of Income Tax Expense to Statutory Federal Income Tax Rate to Loss From Operations
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Segments [Axis]
Long-Lived Tangible Asset [Domain]
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Tax Credits
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Effective Income Tax Rate Reconciliation, Tax Credit, Orphan Drug Credit, Amount
Effective income tax rate reconciliation, tax credit, orphan drug credit, amount.
Orphan drug credit
Orphan drug credit
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation expense
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Deferred Tax Asset, In-Process Research and Development
Research and development tax credits
Changes in valuation allowances
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Ending Balance
Total stockholders' deficit
Beginning Balance
Equity, Attributable to Parent
Total stockholders' equity
Preferred Stock, Par or Stated Value Per Share
Preferred stock par value
Option to extend lease term
Lessee, Operating Lease, Existence of Option to Extend [true false]
Statement of Stockholders' Equity [Abstract]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Follow-on Offering
Follow-on Offering [Member]
Follow-on offering.
Unrecognized tax benefits increases resulting from dissolution of subsidiary
Unrecognized Tax Benefits Increases Resulting from Dissolution of Subsidiary
Unrecognized tax benefits increases resulting from dissolution of subsidiary.
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Changes in Ownership by Stockholders Holding Period
Changes in ownership by stockholders holding period.
Changes in ownership by stockholders holding period
Leaseholds and Leasehold Improvements [Member]
Leaseholds and Leasehold Improvements
Fair Value Measurements
Fair Value Disclosures [Text Block]
Percentage of repurchase rights lapse on one-year anniversary.
Percentage of Repurchase Rights Lapse on One-Year Anniversary
Percentage of repurchase rights lapse on one-year anniversary.
Underwritten Public Offering [Member]
Underwritten public offering
2025 Offering
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Reconciliation of Unrecognized Tax Benefits Recorded in Statement of Operations
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Plan Name [Domain]
Lessee, Operating Lease, Incremental Borrowing Rate
Lessee, operating lease, incremental borrowing rate.
Incremental borrowing rate
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Concentration of Supplier Risk
Concentration Of Supplier Risk Policy [Policy Text Block]
Concentration of supplier risk policy.
Percentage of holding in outstanding common stock
Equity Method Investment, Ownership Percentage
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price
Weighted Average Exercise Price, Vested and exercisable as of December 31, 2025
Current State and Local Tax Expense (Benefit)
State
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights
Award vesting description
Deferred Offering Costs
Deferred Charges, Policy [Policy Text Block]
Related and Nonrelated Parties [Axis]
Other Adjustments
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Shares Sales agreement and Follow-on Offering
Shares Sales Agreement and Follow-on Offering [Member]
Shares sales agreement and follow-on offering.
Foreign Tax Jurisdiction [Member]
Foreign
2024 Inducement Plan
Two Thousand Twenty Four Inducement Stock Incentive Plan [Member]
Two thousand twenty four inducement stock incentive plan.
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment, Net
Entity Address, City or Town
Class of warrants or rights number of shares converted into common stock
Class of Warrants or Rights Number of Shares Converted to Common Stock
Class of warrants or rights number of shares converted to common stock.
Series A-2 convertible preferred stock warrants
Series A-1 Convertible Preferred Stock
Series A-1 Convertible Preferred Stock [Member]
Series A-1 convertible preferred stock.
Number of Reportable Segments
Number of reportable segment
Security Exchange Name
Deferred tax assets right of use liability.
Deferred Tax Assets Right Of Use Liability
Right-of-use liability
Other Adjustments
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Property, Plant and Equipment, Gross, Total
Total property and equipment
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross
Current Income Tax Expense (Benefit), Continuing Operations [Abstract]
Current expense:
Deferred offering costs
Deferred Offering Costs
Net loss before income tax
Net loss before income tax
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Time Based Restricted Stock Units RSU [Member]
Time based restricted stock units RSU.
Time-Based RSUs
Measurement Input Type [Domain]
Impairment or Disposal of Long-Lived Assets, Including Intangible Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Antidilutive Securities, Name [Domain]
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Statutory tax rate difference between local country and United States
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Statistical Measurement [Domain]
Total current assets
Total current assets
Assets, Current
Total stock-based compensation expense
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Period End Date
Document Period End Date
Deferred Tax liabilities right of use asset.
Deferred Tax Liabilities Right Of Use Asset
Right-of-use-Asset
Right-of-use-Asset
Fair Value Hierarchy and NAV [Domain]
ICFR Auditor Attestation Flag
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Stock Options, Vested and exercisable as of December 31, 2025
Professional services
Accrued Professional Services Current
Accrued professional services current.
Statement of Financial Position [Abstract]
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units
Unvested restricted stock units
Redeemable Convertible Preferred Stock
Redeemable Convertible Preferred Stock [Member]
Tax Credit Carryforward Expiration Year
Tax credit carryforward expiration year.
Tax credit carryforward expiration year
Lease, Existence of Option to Terminate [true false]
Antidilutive Security, Excluded EPS Calculation [Table]
Other comprehensive (loss) income:
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Components of cash, cash equivalents and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation [Abstract]
Class of Stock [Axis]
Current Income Tax Expense (Benefit)
Total current expense
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Stock Option Repricing
Stock Option Repricing [Member]
Stock Option Repricing [Member]
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Percent
Effect of Changes in Tax Laws or Rates Enacted in the Current Period
Total liabilities
Total liabilities
Liabilities
Lessee, Operating Lease, Discount Rate
Lease discount rate
Number of shares became restricted and subject to repurchase
Number Of Shares Restricted And Subject To Repurchase
Number of shares restricted and subject to repurchase.
Financial Instruments [Domain]
Platform And External [Member]
Platform And External.
Platform and External
Award requisite service period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Requisite Service Period
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount
Statutory tax rate difference between local country and United States
Lessee, Operating Lease, Liability, to be Paid, Year Two
2027
Restricted Cash, Total
Restricted Cash
Restricted Stock [Member]
Restricted Stock and Performance Stock Units
Exercise of preferred stock warrants
Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Exercise of Preferred Stock Warrants
Fair value measurement with unobservable inputs reconciliations recurring basis liability exercise of preferred stock warrants.
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted-average common shares outstanding, diluted
Weighted Average Number of Shares Outstanding, Diluted
Entity File Number
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized gain (loss) on marketable securities
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent
Other
ASU 2023-07
Accounting Standards Update 2023-07 [Member]
Cover
Cover [Abstract]
US Treasury Notes Securities [Member]
U.S. Treasury Notes
Measurement Input Type [Axis]
Prepaid expenses and other current assets
Prepaid expenses and other assets
Prepaid Expense and Other Assets, Current
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Number of Shares, Forfeited
Number of Shares, Forfeited
Fixed lease rent expense.
Fixed Lease Rent Expense
Fixed lease rent expense
Common stock outstanding percentage
Common Stock Outstanding Percentage
Common stock outstanding percentage
Number of shares authorized and reserved for issuance
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Sale of Stock [Domain]
Segment Reporting Disclosure [Text Block]
Segment Reporting
General and administrative
Total general and administrative expense
Total general and administrative expense
General and administrative expenses
Deferred Tax Assets Intangible Asset Amortization
Intangible asset amortization
Deferred tax assets intangible asset amortization.
Other, net
Deferred Tax Assets, Other
Other Research and Development Expenses
Other Research and Development Expenses [Member]
Other research and development expenses.
Effect of Changes in Tax Laws or Rates Enacted in the Current Period
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Weighted Average Exercise Price, Vested and expected to vest as of December 31, 2025
Property and equipment estimated useful lives
Property, Plant and Equipment, Useful Life
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Pronouncements
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Schedule of Future Minimum Lease Payments Under Non-cancelable Operating Leases
Series B Stock Purchase Agreement
Series B Stock Purchase Agreement [Member]
Series B Stock Purchase Agreement.
Research and development expenses
Accrued Research And Development Expenses Current
Accrued research and development expenses current
Research and development
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Number of shares converted
Stock Issued During Period, Shares, Conversion of Convertible Securities
Conversion of convertible preferred stock upon IPO, shares
At The Market Sales Agreement [Member]
At the market sales agreement.
ATM
Number of common stock vote
Number of Common Stock Vote
Number of common stock vote.
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Domestic
Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract]
Depreciation, Total
Depreciation expense
Depreciation
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized compensation costs related to unvested RSUs
Lease term
Lessee, Operating Lease, Term of Contract
Common stock, shares outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding
Operating Lease, Liability, Current
Operating lease liability
Current portion of lease liability
Depreciation, Depletion and Amortization, Total
Depreciation expenses
Depreciation, Depletion and Amortization
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Deferred Tax Assets, Net
Net deferred tax assets
Total operating expenses
Operating Expenses
Accrued Liabilities, Current [Abstract]
Research and development (including related party amounts of $29 and $475,respectively)
Total research and development expense
Research and development
Research and development expenses
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Schedule of Components of Income Tax Expense
Statement of Cash Flows [Abstract]
Stock Issued During Period, Value, New Issues
Issuance of common stock, Shares
Summary of Stock Options Activity
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Equity [Text Block]
Stockholders' Equity
Dividend Yield
Measurement Input, Expected Dividend Rate [Member]
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Summary of Restricted Stock Units
Deferred Tax Liabilities, Other
Other, net
Other, net
Cybersecurity Risk Management Processes Integrated [Text Block]
Net loss
Net loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Outstanding, Aggregate Intrinsic Value
Fixed lease cost
Operating Lease, Cost
Operating lease cost improvements
Restricted Stock Units RSU And Performance Stock Units PSU [Member]
Restricted stock units RSU and performance stock units PSU.
RSUs and PSUs
Warrants term
Warrants and Rights Outstanding, Term
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Operating Lease, Payments
Operating cash payments for operating leases
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Vested and exercisable, Aggregate Intrinsic Value
Assets
Assets [Abstract]
Income Tax Authority, Name [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate %
Construction in Process
Construction in Progress [Member]
Document Fiscal Year Focus
Other Assets
Other Assets [Member]
Cash flows from investing activities:
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Retirement Benefits [Abstract]
Share-Based Payment Arrangement, Option, Exercise Price Range, Upper Range Limit
Options exercise price, upper limit
Due to related party for service rendered
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Stock Options Issued and Outstanding
Stock options issued and outstanding [Member]
Stock options issued and outstanding.
Options to purchase common stock
Fair value of vested shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Sublicensees threshold amount
Sublicensees Threshold Amount
Sublicensees threshold amount.
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Schedule of Loss Before for Income Taxes
Research and Development Expense [Member]
Research and Development
Non cash Charges
Non cash charges.
Non-cash charges
ASU 2019-12
Accounting Standards Update 2019-12 [Member]
At-the-Market Equity Offering Sales Agreement and Follow-on Offering
At The Market Issuance Sales Agreement And Follow on Offering [Member]
At the market isssuance sales agreement and follow on offering.
Direct Research and Development Expenses
Direct Research and Development Expenses [Member]
Direct research and development expenses.
Tax Credit Carryforward, Expiration Date
Gross proceeds from underwriters exercised option
Proceeds from Stock Options Exercised
Proceeds from exercise of stock options
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Effective Income Tax Rate Reconciliation, Tax Credit, Amount
Effective Income Tax Rate Reconciliation, Tax Credit, Amount, Total
Tax Credits
Lessee, Operating Lease, Liability, to be Paid, Year One
2026
Operating lease increase in monthly rent expense.
Operating Lease Increase In Monthly Rent Expense
Increase in monthly rent expense
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Thereafter
Share-Based Payment Arrangement [Abstract]
Unrecognized compensation expense related to unvested stock options
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Fair value of financial assets
Fair value of financial assets
Assets, Fair Value Disclosure
Sale of Stock [Axis]
PepGen Limited [Member]
PepGen Limited.
PepGen Limited
Net cash used in investing activities
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Title of 12(b) Security
Schedule of Segment Reporting Information, by Segment [Table]
Income Tax Paid, by Individual Jurisdiction [Table]
Weighted Average Exercise price, Canceled/Forfeited
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted-Average Grant Date Fair Value, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Related and Nonrelated Parties [Domain]
Income Taxes
Income Tax Disclosure [Text Block]
Temporary Equity, Shares Issued
Number of shares agreed to issue
Convertible preferred stock shares Issued
PGN-EDODM1 [Member]
PGN-EDODM1
PGN-EDODM1.
Changes in operating assets and liabilities:
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Summary of Cost and Accumulated Depreciation of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Exercise price of options repriced
Weighted Average Exercise Price, Outstanding as of December31, 2025
Weighted Average Exercise Price, Outstanding as of December 31, 2024
Deferred offering costs in AP and accruals
Deferred Offering Costs In Accounts Payable And Accrued Expenses
Deferred offering costs in accounts payable and accrued expenses.
Schedule of Accrued Expenses
Schedule of Accrued Liabilities Current [Table Text Block]
Schedule of accrued liabilities current.
Income Tax Disclosure [Abstract]
Fair Value, Recurring and Nonrecurring [Table]
Unrecognized Tax Benefits
Balance at beginning of the period
Balance at the end of the period
Unrecognized tax benefit
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Changes in Unrecognized Tax Benefits
Effective Income Tax Rate Reconciliation, Changes in Unrecognized Tax Benefits, Amount
Effective income tax rate reconciliation, changes in unrecognized tax benefits, amount.
UNITED KINGDOM
United Kingdom
Oxford, United Kingdom
Measurement Frequency [Domain]
Statement of Income Location, Balance [Axis]
Summary of Significant Accounting Policies [Line Items]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Trading Symbol
Property and Equipment, Net
Property, Plant and Equipment Disclosure [Text Block]
Open Tax Year
Open tax year
Related Party Transaction [Table]
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Nontaxable or Nondeductible Items
Subsequent Event Type [Axis]
Amortization and interest accretion related to operating lease
Amortization and Interest Accretion Related to Operating Leases
Amortization and interest accretion related to operating leases.
Employee-related Liabilities, Current, Total
Employee-related expenses
Employee-related Liabilities, Current
Cash flows from financing activities:
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Fair Value, Measurements, Recurring
Fair Value, Recurring [Member]
Entity Ex Transition Period
Lessee, Operating Lease, Liability, to be Paid
Total future minimum lease payments
ASU 2016-13
Accounting Standards Update 2016-13 [Member]
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: imputed interest
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Research and development credit
R&D
U.K. R&D credit
Effective income tax rate reconciliation, UK R&D credit.
Effective Income Tax Rate Reconciliation, UK R&D credit
Equity Components [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Remaining Contractual Term
Vested and exercisable , Weighted Average Remaining Life
Nonoperating Income (Expense)
Total other income, net
Vesting of restricted stock units, Shares
Stock Issued During Period Shares Restricted Stock Units Vested
Stock issued during period, shares, restricted stock units vested.
Equity Component [Domain]
Document Annual Report
IPO
IPO [Member]
Public Offering
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of stock under the employee stock purchase plan, Shares
US Treasury-Backed Money Market Funds [Member]
US Treasury-backed money market funds.
US Treasury-Backed Money Market Funds
Orphan drug credit
Effective Income Tax Rate Reconciliation, Tax Credit, Orphan Drug Credit, Percent
Effective income tax rate reconciliation, tax credit, orphan drug credit, percent.
Oxford University Innovation Limited
Oxford University Innovation Limited [Member]
Oxford University Innovation Limited
Maximum
Maximum [Member]
Statistical Measurement [Axis]
Weighted Average Exercise price, Exercised
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued
Common stock, $0.0001 par value; 500,000,000 shares authorized as of December 31, 2025 and 2024, respectively; 68,874,944 and 32,619,663 shares issued and outstanding as of December 31, 2025 and 2024, respectively
Expected market return
Expected Market Return
Expected market return.
At-the-Market Equity Offering Sales Agreement and Secondary Offering
At The Market Issuance Sales Agreement And Secondary Offering [Member]
At the market issuance sales agreement and secondary offering.
Lab Equipment
Equipment [Member]
Rent expense
Related Party Transaction, Amounts of Transaction
Deferred Tax Assets, Operating Loss Carryforwards, Total
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carryforwards
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State and Local Income Tax, Net of Federal (National) Income Tax Effect
2024 Inducement Plan
Two Thousand Twenty Four Inducement Plan [Member]
Two thousand twenty four inducement plan.
Sales Agreement
Shares sales agreement.
Shares Sales Agreement
Entity Public Float
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility %
Preferred stock authorized
Preferred Stock, Shares Authorized
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent
Effective Income Tax Rate Reconciliation, Cross-Border Tax Effect, Percent, Total
Effect of Cross-Border Tax Laws
Related Party Transaction [Line Items]
Share-Based Payment Arrangement, Option, Exercise Price Range, Lower Range Limit
Options exercise price, lower limit
Registrant Name
Entity Registrant Name
Effective Income Tax Rate Reconciliation, Changes in Unrecognized Tax Benefits, Percent
Effective income tax rate reconciliation, changes in unrecognized tax benefits, percent.
Changes in Unrecognized Tax Benefits
Unrealized Losses
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Unrealized Losses
Shares subject to repurchase
Shares Of Restricted Stock Subject To Repurchase
Shares Of restricted stock subject to repurchase.
Entity Voluntary Filers
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other (expense) income, net
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Supplemental disclosure of cash flow information related to leases
Supplemental Disclosure Of Cash Flow Information Related To Leases [Table Text Block]
Supplemental Disclosure of Cash Flow Information Related to Leases
Income Tax Expense (Benefit)
Provision for income taxes
Income tax (expense) benefit
Income tax (expense) benefit
Income tax expense
Income tax (expense) benefit
Measurement Frequency [Axis]
Proceeds from Issuance of Common Stock
Issuance and sale of shares of common stock
Issuance of common stock from At-the-Market Sales Agreement, net of underwriters' fees
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Laboratory and computer equipment.
Laboratory And Computer Equipment [Member]
Laboratory and Computer Equipment
Entity Common Stock, Shares Outstanding
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of Credit Risk
Lessee, Operating Lease, Remaining Lease Term
Remaining lease term
Authorized for Future Stock Awards or Option Grants
Authorized for future stock awards or option grants [Member]
Authorized for future stock awards or option grants.
Accumulated other comprehensive (loss) income
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive income
Schedule of Reserved Shares of Common Stock for Issuance, on an As-Converted Basis
Schedule Of Common Stock Shares Reserved For Issuance [Table Text Block]
Schedule of common stock shares reserved for issuance.
Stifel, Nicolaus And Company [Member]
Stifel, nicolaus and company.
Stifel, Nicolaus & Company
Debt Securities, Available-for-Sale, Allowance for Credit Loss [Table]
Commitments and Contingencies, Policy [Policy Text Block]
Commitment and Contingencies
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Payments to Acquire Property, Plant, and Equipment
Comprehensive loss.
Comprehensive Loss [Policy Text Block]
Comprehensive Loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Number of Shares, Granted
Operating lease commencement date.
Operating Lease Commencement Date
Lease commencement date
Total assets
Total assets
Assets
Property, Plant and Equipment [Table]
Income Statement [Abstract]
Effective income tax rate reconciliation, permanent differences.
Effective Income Tax Rate Reconciliation, Permanent Differences
Permanent Adjustments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Fair Value Measurements
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Decrease related to prior year tax positions
Decrease related to prior year tax positions
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Permanent Adjustments
Effective Income Tax Rate Reconciliation, Permanent Differences, Amount
Effective income tax rate reconciliation, permanent differences, amount.
Effective Income Tax Rate Reconciliation, GILTI, Percent
GILTI Inclusion
GILTI Inclusion
Number of shares sold
Stock Issued During Period, Shares, New Issues
Issuance of common stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Number of Shares, Vested
Number of Shares, Vested
Earnings Per Share, Diluted, Total
Net loss per share, diluted
Earnings Per Share, Diluted
Fair Value, Option, Quantitative Disclosures [Line Items]
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Schedule of Functional Operating Expenses
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Accounts payable
Increase (Decrease) in Accounts Payable, Trade
City Area Code
Auditor Name
Research and Development and General and Administrative Expense
Research and Development and General and Administrative Expense [Member]
Research and development and general and administrative expense.
Income Tax Examination, Penalties and Interest Expense
Interest or penalties were recognized
Interest or penalties were recognized
RA Capital Management, L.P. [Member]
RA Capital Management, L.P.
RA Capital Management, L.P.
Tax credits
Deferred Tax Assets, Tax Credit Carryforwards
Deferred Tax Assets, Tax Credit Carryforwards, Total
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Research and development tax credits
R&D
Income Tax Benefit
Income tax benefit.
Income tax benefit
Variable lease cost
Variable Lease, Cost
Issuance of stock under the employee stock purchase plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Segment Reporting Information [Line Items]
Reverse stock split, conversion ratio
Stockholders' Equity Note, Stock Split, Conversion Ratio
2022 Plan
Two Thousand Twenty Two Equity Incentive Award Plan [Member]
Two thousand twenty two equity incentive award plan.
Lease, Cost
Total lease cost
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Total property and equipment, net
Total property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number
Stock Options, Vested and expected to vest as of December 31, 2025
Cash, cash equivalents and restricted cash at beginning of period
Total cash, cash equivalents and restricted cash at end of period
Cash, cash equivalents and restricted cash at beginning of period
Cash, cash equivalents and restricted cash at end of period
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation
Operating loss
Operating Income (Loss)
Loss from operations
Accumulated Deficit
Retained Earnings [Member]
Share-based Payment Arrangement, Noncash Expense, Total
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Underwriter's fees
Issuance costs of Series B convertible preferred stock
Net of issuance costs
Underwriter's fees and offering costs
Newton Massachusetts.
Newton Massachusetts [Member]
Newton, Massachusetts
Property and equipment included in accounts payable and accrued expenses
Property and equipment included in accounts payable and accrued expenses.
Property and equipment included in accounts payable and accrued expenses
Operating Lease, Liability, Noncurrent
Operating lease liability, net of current portion
Non-current portion of lease liability
Level 1
Fair Value, Inputs, Level 1 [Member]
Class of Stock [Line Items]
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Net cash provided by financing activities
Lease, Cost [Table Text Block]
Components of Lease Cost
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Auditor Location
Marketable Securities
Investments, Fair Value Disclosure
Investments, Fair Value Disclosure, Total
Nonoperating Income (Expense) [Abstract]
Other income (expense):
Summary of Marketable Securities
Marketable Securities [Table Text Block]
Cambridge Massachusetts.
Cambridge Massachusetts [Member]
Cambridge, Massachusetts
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Summary of Outstanding Potentially Dilutive Securities Excluded in Calculation of Diluted Net Loss per Share
Income Tax Jurisdiction [Domain]
Entity Interactive Data Current
Deferred Tax Liabilities, Gross [Abstract]
Deferred tax liabilities
Statement of Income Location, Balance [Domain]
Cash flows from operating activities:
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Furniture and Fixtures [Member]
Furniture and Fixtures
Accretion (Amortization) of Discounts and Premiums, Investments
Amortization of premiums and accretion of discounts on marketable securities, net
Aggregate potential milestone payments
Aggregate Potential Milestone Payments
Aggregate potential milestone payments.
Change in fair value
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings
Entity Tax Identification Number
Share Price
Share price
2022 Employee Stock Purchase Plan
Two Thousand Twenty Two Employee Stock Purchase Plan [Member]
Two thousand twenty two employee stock purchase plan.
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale
Maturities of marketable securities
Secondary Offering
Secondary Offering [Member]
Secondary Offering.
Income Tax Authority, Name [Domain]
Deferred tax assets capitalized research and development costs.
Deferred Tax Assets Capitalized Research And Development Costs
Capitalized Section 174 R&D Costs
Net proceeds issuance or sale of equity
Proceeds from Issuance or Sale of Equity
Proceeds from Issuance or Sale of Equity, Total
Local Phone Number
Personnel-related (Including Stock-based Compensation) [Member]
Personnel-related (including stock-based compensation).
Personnel-related (Including Stock-based Compensation)
Related Party Transaction [Domain]
Series B Convertible Preferred Stock
Series B Convertible Preferred Stock [Member]
Series B convertible preferred stock.
Short-Term Lease, Cost
Short-term lease cost
Auditor Opinion [Text Block]
Unrecognized tax benefits, interest on income taxes expense
Unrecognized Tax Benefits, Interest on Income Taxes Expense
Accounting Policies [Abstract]
Authorized for Future Issuance under Employee Stock Purchase Plan
Authorized for Future Issuance under Employee Stock Purchase Plan [Member]
Authorized for future issuance under employee stock purchase plan.
General and Administrative Expense [Abstract]
General and Administrative Expenses
Lessee, Operating Lease, Liability, to be Paid, Year Four
2029
PGN-EDO51 [Member]
PGN-EDO51.
PGN-EDO51
Class of Stock [Domain]
General and Administrative and Research and Development Expense [Member]
General and administrative and research and development expense.
General and Administrative and Research and Development Expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Shares remaining available for issuance
Expected recognition period of unrecognized compensation cost related to unvested share options
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Cash, cash equivalents and marketable securities
Cash, Cash Equivalents, and Short-Term Investments
Cash, Cash Equivalents, and Short-Term Investments, Total
Stock, Class of Stock [Table]
Entity Emerging Growth Company
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Vested and expected to vest, Weighted Average Remaining Life