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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
9 Months Ended 12 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Dec. 31, 2020
Dec. 31, 2019
Revenue        
Total revenue $ 2,888 $ 9,350 $ 9,384 $ 32,562
Cost and operating expenses:        
Cost of product revenue 3,585 1,341 1,718 998
Research and development 24,943 21,766 28,084 35,698
Selling, general, and administrative 45,811 33,645 56,226 27,469
Total cost and operating expenses 74,339 56,752 86,028 64,165
Loss from operations (71,451) (47,402) (76,644) (31,603)
Other income (expenses):        
Interest and other (expense) income, net (3,086) (926) (2,562) 1,415
Change in estimated fair value of warrant liabilities (7,302) (48) (795) 1
Amortization of deferred gain on note payable to collaboration partner     0 544
Loss on issuance of convertible preferred stock (2,053) 0 (16,819) 0
(Loss) gain on extinguishment of debt 0 (999) (998) 20,310
Total other (expense) income (12,441) (1,973) (20,379) 22,269
Net loss (83,892) (49,375) (97,023) (9,334)
Unrealized (loss) gain on short-term investments 0 (25) (29) 33
Comprehensive loss $ (83,892) $ (49,400) (97,052) (9,301)
Loss on repurchase of convertible preferred stock     (11,053) 0
Net loss attributable to common stockholders     (108,076) (9,334)
Net loss attributable to common stockholders     $ (108,076) $ (9,334)
Net loss per share:        
Diluted (in dollars per share) $ (7.31) $ (3.29) $ (7.32) $ (0.63)
Basic (in dollars per share) $ (7.31) $ (3.29) $ (7.32) $ (0.63)
Weighted average common shares outstanding:        
Weighted-average common shares outstanding, diluted (in shares) 11,481,620 15,008,629 14,761,577,000 14,760,682,000
Weighted-average common shares outstanding, basic (in shares) 11,481,620 15,008,629 14,761,577,000 14,760,682,000
Product revenue        
Revenue        
Total revenue $ 2,550 $ 115 $ 149 $ 65
Collaboration and license revenue        
Revenue        
Total revenue $ 338 $ 9,235 $ 9,235 $ 32,497