X0306 4 2023-03-14 0001833214 SAB Biotherapeutics, Inc. SABS 0001825323 Kropotova Alexandra 2100 E 54TH STREET NORTH SIOUX FALLS SD 57104 1 Chief Medical Officer Common Stock 2023-03-14 4 A 0 275000 A 275000 D Restricted Stock Unit ("RSU") award under the 2021 Equity Incentive Plan, which vests over a four-year service period, with the first 25% vesting on March 14, 2024, and the remaining vesting in even monthly increments thereafter. The RSU award is subject to the reporting person's continued employment through the vesting date. Each RSU represents a contingent right to receive one share of the Issuer's common stock. /s/ Alexandra Kropotova 2023-03-16