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			<nameOfIssuer>CARIBOU BIOSCIENCES INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>142038108</cusip>
			<value>11316</value>
			<shrsOrPrnAmt>
				<sshPrnamt>474067</sshPrnamt>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<otherManager>0</otherManager>
			<votingAuthority>
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				<Shared>474067</Shared>
				<None>0</None>
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		<infoTable>
			<nameOfIssuer>OMEGA THERAPEUTICS INC</nameOfIssuer>
			<titleOfClass>COMMON STOCK</titleOfClass>
			<cusip>68217N105</cusip>
			<value>6653</value>
			<shrsOrPrnAmt>
				<sshPrnamt>352941</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<otherManager>0</otherManager>
			<votingAuthority>
				<Sole>0</Sole>
				<Shared>352941</Shared>
				<None>0</None>
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		<infoTable>
			<nameOfIssuer>PRAXIS PRECISION MEDICINES I</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>74006W108</cusip>
			<value>18287</value>
			<shrsOrPrnAmt>
				<sshPrnamt>988995</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<otherManager>0</otherManager>
			<votingAuthority>
				<Sole>0</Sole>
				<Shared>988995</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>PROMETHEUS BIOSCIENCES INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>74349U108</cusip>
			<value>43817</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1848024</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<otherManager>0</otherManager>
			<votingAuthority>
				<Sole>0</Sole>
				<Shared>1848024</Shared>
				<None>0</None>
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		</infoTable>
</informationTable>
