Commitments and Contingencies - Additional Information (Details) $ in Thousands			1 Months Ended	3 Months Ended		6 Months Ended
		Sep. 14, 2021 USD ($) ft²	Apr. 30, 2022 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Apr. 01, 2022 USD ($)	Jan. 01, 2022 USD ($)	Dec. 31, 2021 USD ($)	Feb. 29, 2016 USD ($)
Long-Term Purchase Commitment [Line Items]
Lease term		5 years		2 years		2 years
Lease space | ft²		9,600
Monthly rental payments		$ 400
Operating lease liabilities within twelve months				$ 1,000		$ 1,000
Operating lease liability, non-current				$ 1,889		1,889			$ 1,426	$ 0	$ 1,400
Rent expense						$ 700
Weighted-average remaining lease term				3 years 2 months 12 days		3 years 2 months 12 days
Weighted-average incremental borrowing rate				6.00%		6.00%
Accrued Expenses				$ 52,624		$ 52,624				$ 56,277
Research and development expense	[1]			37,129	$ 35,067	129,164	$ 69,204
A D G20 Drug Substance
Long-Term Purchase Commitment [Line Items]
Purchase Obligation								$ 107,800
Minimum | A D G20 Drug Substance
Long-Term Purchase Commitment [Line Items]
Purchase Obligation								$ 159,400
A&R Commercial Manufacturing Agreement
Long-Term Purchase Commitment [Line Items]
Credit received from deposits previously paid for the cancelled batches						13,800
Future minimum payments under non-cancelable purchase obligations				19,600		19,600
Manufactured Volume			$ 51,600
A&R Commercial Manufacturing Agreement | Deposits For Cancelled Batches
Long-Term Purchase Commitment [Line Items]
Future minimum payments under non-cancelable purchase obligations				5,800		5,800
Accrued Expenses				13,800		13,800
A&R Commercial Manufacturing Agreement | Prepaid Expenses and Other Current Assets
Long-Term Purchase Commitment [Line Items]
Future minimum payments under non-cancelable purchase obligations				$ 2,400		$ 2,400

[1] Includes related-party amounts of $2,285 and $4,285 for the three and six months ended June 30, 2022, respectively,