X0306 4 2022-06-22 0 0001832038 Adagio Therapeutics, Inc. ADGI 0001830496 Elia Marc C/O ADAGIO THERAPEUTICS, INC. 1601 TRAPELO ROAD, SUITE 178 WALTHAM MA 02451 1 0 0 1 See Remarks 0001807489 M28 Capital Management LP 700 CANAL STREET, 2ND FLOOR STAMFORD CT 06902 0 0 0 1 See Remarks Stock Option (Right to Buy) 3.09 2022-06-22 4 A 0 150000 0.00 A 2032-06-21 Common Stock 150000 150000 D This option was granted on June 22, 2022 and vests over a three-year period, with one-third of the shares subject to the grant vesting on the first anniversary of the grant date and 1/36th of the shares subject to the grant vesting in equal monthly installments thereafter, subject to continued service through each vesting date. The grant was awarded to Marc Elia ("Mr. Elia"). Mr. Elia is deemed to hold the grant for the benefit of M28 Capital Management LP ("M28 Capital Management") and the funds managed by M28 Capital Management. M28 Capital Management may be deemed to be a director by deputization for purposes of Section 16 under the Securities Exchange Act of 1934, as amended, by virtue of the fact that Mr. Elia, who indirectly controls M28 Capital Management, currently serves on the board of directors of the Issuer. Exhibit Index: 24.1 Power of Attorney /s/ Jill Andersen attorney-in-fact for Marc Elia 2022-06-24 M28 Capital Management LP, By: Jill Andersen attorney-in-fact for Marc Elia 2022-06-24