SCHEDULE 13G/A 0001493152-23-038513 0001831942 XXXXXXXX LIVE 2 Common Stock, $0.0001 par value per share 12/31/2024 0001787400 Nkarta, Inc. 65487U108 1150 Veterans Boulevard South San Francisco CA 94080 Rule 13d-1(c) COMMODORE CAPITAL LP DE 0.00 351848.00 0.00 351848.00 351848.00 N 0.5 IA See Item 2 for additional information. Commodore Capital Master LP E9 0.00 351848.00 0.00 351848.00 351848.00 N 0.5 OO See Item 2 for additional information. Nkarta, Inc. 1150 Veterans Boulevard, South San Francisco, California 94080 This report on Schedule 13G is being filed by Commodore Capital LP, a Delaware limited partnership (the "Firm") and Commodore Capital Master LP, a Cayman Islands exempted limited partnership ("Commodore Master"). The Firm is the investment manager to Commodore Master. As of December 31, 2024, the Firm may be deemed to beneficially own an aggregate of 351,848 shares of common stock, $0.0001 par value per share (the "Common Stock"), of the Issuer. The Firm, as the investment manager to Commodore Master, may be deemed to beneficially own these securities. Michael Kramarz and Robert Egen Atkinson are the managing partners of the Firm and exercise investment discretion with respect to these securities. Ownership percentages are based on 70,568,754 shares of Common Stock reported as issued and outstanding as of November 4, 2024 in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 7, 2024. The address for the Firm and Commodore Master is: 444 Madison Avenue, Floor 35, New York, New York 10022. The Firm is a Delaware limited partnership and Commodore Master is a Cayman Islands exempted limited partnership. Y 351,848.00 0.5 0 351,848.00 0 351,848.00 N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. 1. Joint Filing Agreement dated as of October 27, 2023, by and between Commodore Capital LP and Commodore Capital Master LP (incorporated by reference to Exhibit 1 to the Schedule 13G filed with the Securities and Exchange Commission on October 27, 2023). COMMODORE CAPITAL LP /s/ Michael Kramarz 02/14/2025 Commodore Capital Master LP /s/ Michael Kramarz 02/14/2025