X0306 4 2021-05-20 0 0001802665 Harmony Biosciences Holdings, Inc. HRMY 0001831815 Motley Eric L C/O HARMONY BIOSCIENCES HOLDINGS, INC. 630 W. GERMANTOWN PIKE, SUITE 215 PLYMOUTH MEETING PA 19462 1 0 0 0 Stock Option 32.50 2021-05-20 4 A 0 7246 0.00 A 2031-05-20 Common Stock 7246 7246 D The stock option shall vest in full on the earlier to occur of (i) May 20, 2022 and (ii) the date of the next annual meeting following the grant date, subject to continued service through the applicable vesting date. /s/ Christian Ulrich, Attorney-in-fact for Eric Motley 2021-06-14