X0206 3 2020-11-04 0 0000810509 NAVIDEA BIOPHARMACEUTICALS, INC. NAVB 0001831425 Kaufman Joel H. 4995 BRADENTON AVE., SUITE 240 DUBLIN OH 43017 1 Chief Business Officer Common Stock 24645 D Common Stock 5723 D Stock Option 9.4000 2027-10-27 Common Stock 15000 D Stock Option 7.2000 2028-02-20 Common Stock 1200 D Stock Option 3.0000 2029-02-07 Common Stock 2400 D Stock Option 1.0600 2030-02-06 Common Stock 6000 D Stock options granted pursuant to Issuer's Amended and Restated 2014 Stock Incentive Plan, which vest as to one-third (1/3) on each of the first three anniversaries of the date of grant. Held in the Company's 401(k) Plan on behalf of the Officer. /s/ Jed A. Latkin for Joel H. Kaufman, by power of attorney 2020-11-06