X0508 4 2023-11-08 0001830214 Ginkgo Bioworks Holdings, Inc. DNA 0001845677 Kelly Jason R C/O GINKGO BIOWORKS HOLDINGS 27 DRYDOCK AVENUE BOSTON MA 02210 1 1 See remarks 1 Class A Common Stock 2023-11-08 4 S 0 100000 1.502 D 5394680 D Class A Common Stock 2023-11-09 4 S 0 100000 1.291 D 5294680 D The shares were sold pursuant to a sales plan adopted by the Reporting Person and intended to comply with Rule 10b5-1 under the Securities Exchange Act of 1934. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.48 to $1.57, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.26 to $1.37, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. CEO & Founder /s/ Karen Tepichin, Attorney-in-Fact 2023-11-13