Basis of Presentation and Summary of Significant Accounting Policies (Tables)

6 Months Ended

Jun. 30, 2023

Accounting Policies [Abstract]

Summary of Condensed Consolidated Statements of Operations and Comprehensive Loss

Select line items from the condensed consolidated statement of operations and comprehensive loss reflecting the adoption of ASC 842 are as follows (in thousands):

	Three Months Ended June 30, 2022									Six Months Ended June 30, 2022
	As Previously Reported			Adjustments			As Adjusted			As Previously Reported			Adjustments			As Adjusted
Costs and operating expenses:
Research and development	$	289,188		$	871		$	290,059		$	611,908		$	1,727		$	613,635
Total operating expenses		791,526			871			792,397			1,634,446			1,727			1,636,173
Loss from operations		(646,908	)		(871	)		(647,779	)		(1,321,423	)		(1,727	)		(1,323,150	)
Other income (expense):
Interest income, net		1,674			590			2,264			1,277			1,164			2,441
Other income (expense), net		(51	)		281			230			1,586			563			2,149
Total other income (expense), net		(23,707	)		871			(22,836	)		58,031			1,727			59,758

Summary of condensed consolidated statements of stockholders' equity reflecting the adoption of ASC 842

Select line items from the condensed consolidated statements of stockholders’ equity reflecting the adoption of ASC 842 are as follows (in thousands):

	As of June 30, 2022
	As Previously Reported			Adjustments		As Adjusted
Accumulated deficit	$	(3,557,255	)	$	5,195	$	(3,552,060	)
Total stockholders' equity		1,567,056			5,195		1,572,251

Summary of condensed consolidated statements of cash flows reflecting the adoption of ASC 842

Select line items from the condensed consolidated statements of cash flows reflecting the adoption of ASC 842 are as follows (in thousands):

	Six Months Ended June 30, 2022
	As Previously Reported			Adjustments			As Adjusted
Cash flows from operating activities:
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	$	19,096		$	(1,128	)	$	17,968
Amortization of finance lease right-of-use assets		—			1,004			1,004
Non-cash lease expense		—			7,536			7,536
Changes in operating assets and liabilities:
Prepaid expenses and other current assets		4,973			(600	)		4,373
Accrued expenses and other current liabilities		(12,758	)		(123	)		(12,881	)
Operating lease liabilities, current and non-current		—			(5,332	)		(5,332	)
Deferred rent, non-current		1,468			(1,468	)		—
Cash flows from financing activities:
Principal payments on finance leases		—			(609	)		(609	)
Principal payments on capital leases and lease financing obligation		(720	)		720			—