Investments and Equity Method Investments (Tables)

9 Months Ended

Sep. 30, 2022

Equity Method Investments and Joint Ventures [Abstract]

Schedule of Investments and Equity Method Investments

Investments and equity method investments consisted of the following (in thousands):

	As of September 30,		As of December 31,
	2022		2021
Investments:
Genomatica, Inc. preferred stock	$	44,885	$	55,000
Synlogic, Inc. common stock		6,024		15,345
Synlogic, Inc. warrants		2,421		6,166
Marketable equity securities		16,437		10,331
Non-marketable equity securities		17,543		15,195
SAFE		9,000		—
Total	$	96,310	$	102,037
Equity method investments (1):
Joyn Bio, LLC	$	—	$	11,694
BiomEdit, LLC		3,013		—
Other		1,122		1,500
Total	$	4,135	$	13,194

(1) Equity method investments in Platform Ventures with a carrying value of zero as of September 30, 2022 and December 31, 2021 were excluded from the table.

Schedule of (losses) gains on investments and equity method investments

(Losses) gains on investments and equity method investments consisted of the following (in thousands):

	Three Months Ended September 30,						Nine Months Ended September 30,
	2022			2021			2022			2021
(Loss) gain on investments:
Synlogic, Inc. common stock	$	(1,268	)	$	(5,327	)	$	(9,321	)	$	5,642
Synlogic, Inc. warrants		(510	)		(2,140	)		(3,746	)		2,268
Genomatica, Inc.		—			—			(10,115	)		—
Marketable equity securities		215			(4,901	)		(16,604	)		(4,901	)
Non-marketable equity securities		(195	)		—			(195	)		—
Total	$	(1,758	)	$	(12,368	)	$	(39,981	)	$	3,009
Loss on equity method investments:
Joyn Bio, LLC (1)	$	(5,226	)	$	(4,192	)	$	(15,637	)	$	(12,567	)
Allonnia, LLC		—			—			—			(12,698	)
Arcaea, LLC		—			(35,459	)		—			(47,356	)
Verb Biotics, LLC		—			—			(15,900	)		—
BiomEdit, LLC		(1,308	)		—			(5,860	)		—
Ayana, LLC		(15,989	)		—			(15,989	)		—
Other		(188	)		—			(378	)		—
Total	$	(22,711	)	$	(39,651	)	$	(53,764	)	$	(72,621	)

(1) The loss on equity method investment in Joyn in excess over the carrying value of zero of the equity method investment in Joyn during the three and nine months ended September 30, 2022 was recorded as a reduction to the convertible promissory notes receivable from Joyn (see Note 14).