X0206 3/A 2021-09-16 2021-09-20 0 0001830214 Ginkgo Bioworks Holdings, Inc. DNA 0001296549 Belldegrun Arie C/O GINKGO BIOWORKS HOLDINGS, INC. 27 DRYDOCK AVENUE BOSTON MA 02210 1 0 0 0 Class A Common Stock 18741 D Class A Common Stock 500000 I By Bellco Legacy LLC Warrants 11.50 2021-10-16 2026-09-16 Class A Common Stock 3748 D Reflects shares of Class A Common Stock acquired in a pro rata distribution in-kind, the acquisition of which was exempt pursuant to Rule 16a-9. Bellco Legacy LLC is owned and managed by trusts controlled by the reporting person and Rebecka Belldegrun. /s/ Karen Tepichin, Attorney-in-fact 2022-03-28