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Summary of significant accounting policies (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Disclosure of voluntary change in accounting policy [line items]    
Research and development costs $ 6,186 $ 4,143
Depreciation and amortization expense (580) (474)
Net loss $ 6,959 $ 5,644