<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-07-28</periodOfReport>

    <issuer>
        <issuerCik>0001828852</issuerCik>
        <issuerName>Mondee Holdings, Inc.</issuerName>
        <issuerTradingSymbol>MOND</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000895421</rptOwnerCik>
            <rptOwnerName>MORGAN STANLEY</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1585 BROADWAY</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Class A Common Stock, par value $0.0001 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2022-07-28</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>2346</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>7.694</value>
                    <footnoteId id="F3"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2346</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Class A Common Stock, par value $0.0001 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2022-07-28</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>6252</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>8.682</value>
                    <footnoteId id="F4"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>8598</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Class A Common Stock, par value $0.0001 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>9690567</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">These shares of Class A Common Stock, par value $0.0001 per share (&quot;Common Stock&quot;) were purchased and are held by an indirect subsidiary (the &quot;MS Reporting Unit&quot;) of Morgan Stanley (&quot;MS&quot;). As the indirect parent of the holder of these shares of Common Stock, MS may be deemed to beneficially own shares of Common Stock beneficially owned by the MS Reporting Unit. This filing does not reflect securities, if any, beneficially owned by any operating units of MS whose ownership of securities is disaggregated from that of the MS Reporting Unit in accordance with the Securities and Exchange Commission Release No. 34-39538 (January 12, 1998).</footnote>
        <footnote id="F2">MS disclaims beneficial ownership of the shares Common Stock included herein, except to the extent of its pecuniary interest therein, if any, and the inclusion of the shares of Common Stock in this report shall not be deemed to constitute an admission of beneficial ownership of the reported shares for the purposes of Section 13(d) or Section 16 of the Securities Exchange Act of 1934, or for any other purpose.</footnote>
        <footnote id="F3">The price reported in Column 4 is a weighted average price. These shares of Common Stock of Mondee Holdings, Inc. (the &quot;Issuer&quot;) were purchased in multiple transactions at prices ranging from $7.30 to $8.29, inclusive. The Reporting Person undertakes to provide to any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares of Common Stock purchased at each separate price within the ranges set forth in the footnotes of this Form 4.</footnote>
        <footnote id="F4">The price reported in Column 4 is a weighted average price.  These shares of Common Stock of the Issuer were purchased in multiple transactions at prices ranging from $8.30 to $8.90, inclusive. The Reporting Person undertakes to provide to any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares of Common Stock purchased at each separate price within the ranges set forth in the footnotes of this Form 4.</footnote>
        <footnote id="F5">MS is the indirect parent of the general partners of the funds (the &quot;Private Funds&quot;) that hold these shares of Common Stock. The investment manager to the Private Funds is an indirect subsidiary of MS.  MS may be deemed to  beneficially own the shares of Common Stock held by the Private Funds.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Morgan Stanley, By: /s/ Mustufa Salehbhai, as Authorized Signatory</signatureName>
        <signatureDate>2022-08-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
