<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-07-18</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001828852</issuerCik>
        <issuerName>Mondee Holdings, Inc.</issuerName>
        <issuerTradingSymbol>MOND</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000895421</rptOwnerCik>
            <rptOwnerName>MORGAN STANLEY</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1585 BROADWAY</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001535639</rptOwnerCik>
            <rptOwnerName>MS Capital Partners Adviser Inc</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1585 BROADWAY</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isTenPercentOwner>true</isTenPercentOwner>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Class A Common Stock, par value $0.0001 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>9690567</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">This statement is being filed by Morgan Stanley (&quot;MS Parent&quot;) and MS Capital Partners Adviser Inc. (&quot;Adviser&quot;). MS Parent is the indirect parent of the general partners of the funds (the &quot;Private Funds&quot;) that hold these shares of Class A Common Stock, par value $0.0001 per share (&quot;Common Stock&quot;). The Adviser, an indirect subsidiary of MS Parent, is the investment manager to the Private Funds.  Each of MS Parent and the Adviser may be deemed to beneficially own the shares of Common Stock held by the Private Funds.</footnote>
        <footnote id="F2">Each of MS Parent and the Adviser disclaims beneficial ownership of the shares of Common Stock included herein except to the extent of its pecuniary interest therein, if any, and the inclusion of the shares of Common Stock in this report shall not be deemed to constitute an admission of beneficial ownership of such shares of Common Stock for the purposes of Section 13(d) or Section 16 of the Securities Exchange Act of 1934, or for any other purpose.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Morgan Stanley, By: /s/ Mustufa Salehbhai , as Authorized Signatory</signatureName>
        <signatureDate>2022-08-23</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>MS Capital Partners Adviser Inc., By: Debra Abramovitz, as Authorized Signatory</signatureName>
        <signatureDate>2022-08-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
