X0306 4 2022-01-14 0 0001828673 HCW Biologics Inc. HCWB 0001866276 Rhode Peter C/O HCW BIOLOGICS INC 2929 N. COMMERCE PARKWAY MIRAMAR FL 33025 0 1 0 0 See Remarks Common Stock 2022-01-14 4 M 0 1714 0.21 A 48499 D Common Stock 2022-01-14 4 M 0 1 0.14 A 48500 D Stock Option Grant (Right to Buy) 0.21 2022-01-14 4 M 0 1714 0.00 D 2030-12-22 Common Stock 1714 6857 D Stock Option Grant (Right to Buy) 0.14 2022-01-14 4 M 0 1 0.00 D 2029-12-19 Common Stock 1 51427 D 20% of the total shares subject to the stock option grant vested on December 22, 2021; 20% of the total shares subject to the stock option grant will vest on December 22, 2022; 25% of the total shares subject to the stock option grant will vest on December 22, 2023; and 35% of the total shares subject to the stock option grant will vest on December 22, 2024, subject to the reporting person's continuous service through the applicable vesting date. These option shares were part of a stock option grant covering 85,713 shares of common stock. 20% of the total shares subject to the stock option grant vested on May 30, 2020; 20% of the total shares subject to the stock option grant vested on May 30, 2021; 25% of the total shares subject to the stock option grant will vest on May 30, 2022; and 35% of the total shares subject to the stock option grant will vest on May 30, 2023, subject to the reporting person's continuous service through the applicable vesting date. Title of the Officer: Chief Scientific Officer and Vice President of Clinical Operations. /s/ Nicole Valdivieso, as Attorney-in-Fact for Peter Rhode 2022-01-19