X0206 3 2021-07-19 0 0001828673 HCW Biologics Inc. HCWB 0001866276 Rhode Peter C/O HCW BIOLOGICS INC 2929 N. COMMERCE PARKWAY MIRAMAR FL 33025 0 1 0 0 See Remarks Common Stock 34285 D Stock Option (Right to Buy) 0.14 2029-12-19 Common Stock 51428 D Stock Option (Right to Buy) 0.21 2030-12-22 Common Stock 8571 D These option shares were part of a stock option grant covering 85,713 shares of common stock. 20% of the total shares subject to the stock option grant vested on May 30, 2020; 20% of the total shares subject to the stock option grant vested on May 30, 2021; 25% of the total shares subject to the stock option grant will vest on May 30, 2022; and 35% of the total shares subject to the stock option grant will vest on May 30, 2023, subject to his continuous service through the applicable vesting date. 20% of the total shares subject to the stock option grant will vest on December 22, 2021; 20% of the total shares subject to the stock option grant will vest on December 22, 2022; 25% of the total shares subject to the stock option grant will vest on December 22, 2023; and 35% of the total shares subject to the stock option grant will vest on December 22, 2024, subject to his continuous service through the applicable vesting date. Title of the Officer: Chief Scientific Officer and Vice President of Clinical Operations Exhibit 24.1: Power of Attorney /s/ Hing C. Wong, as Attorney-in-Fact for Peter Rhode 2021-07-19