X0306 4 2021-12-14 0 0001828443 Ortho Clinical Diagnostics Holdings plc OCDX 0001168580 MAC MAHON THOMAS P C/O ORTHO CLINICAL DIAGNOSTICS HOLDINGS 1001 ROUTE 202 RARITAN NJ 08869 1 0 0 0 Ordinary Shares, $0.00001 par value 2021-12-14 5 G 0 E 79669 0.00 D 62184 D Ordinary Shares, $0.00001 par value 2021-12-14 5 G 0 E 79669 0.00 A 79669 I By Trust Includes (i) 27,584 Ordinary Shares held by Trust 1, (ii) 27,584 Ordinary Shares held by Trust 2 and (iii) 24,501 Ordinary Shares held by Trust 3. Mr. Mac Mahon is the trustee for each of these trusts, which are for the benefit of family members of Mr. Mac Mahon. /s/ Michael A. Schlesinger, Attorney-in-Fact 2021-12-17