X0306 4 2021-08-02 0 0001828443 Ortho Clinical Diagnostics Holdings plc OCDX 0001436707 Smith Christopher M C/O ORTHO CLINICAL DIAGNOSTICS HOLDINGS 1001 ROUTE 202 RARITAN NJ 08869 1 1 0 0 Chairman and CEO Ordinary Shares, $0.00001 par value 2021-08-02 4 S 0 103213 22.1003 D 534147 D Ordinary Shares, $0.00001 par value 2021-08-03 4 S 0 104987 21.5534 D 429160 D Ordinary Shares, $0.00001 par value 2021-08-04 4 S 0 61800 21.79 D 367360 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Reporting Person undertakes to provide, upon request by the Securities Exchange Commission staff, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each separate price for all transactions reported in this Form 4. Represents the weighted average sales price for the price increments from $21.90 to $22.51. Represents the weighted average sales price for the price increments from $21.00 to $21.90. Represents the weighted average sales price for the price increments from $21.57 to $21.92. /s/ Michael A. Schlesinger, Attorney-in-Fact 2021-08-04