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                       April 8, 2022

       Joseph M. Busky
       Chief Financial Officer
       Ortho Clinical Diagnostics Holdings plc
       1001 Route 202
       Raritan, New Jersey 08869

                                                        Re: Ortho Clinical
Diagnostics Holdings plc
                                                            Form 10-K For the
fiscal year ended January 2, 2022
                                                            Filed March 8, 2022
                                                            File No. 001-39956

       Dear Mr. Busky:

              We have completed our review of your filing. We remind you that
the company and its
       management are responsible for the accuracy and adequacy of their
disclosures, notwithstanding
       any review, comments, action or absence of action by the staff.




                       Sincerely,


                       Division of Corporation Finance

                       Office of Life Sciences