Commitments and Contingencies - Effective data of the lease term (Details) $ in Thousands			3 Months Ended	12 Months Ended
	Jun. 14, 2022 USD ($) item	Sep. 03, 2021 USD ($) item	Mar. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)
Commitment and Contingencies
Number of square feet under lease agreement | item		31,000
Leases
Right-of-use asset			$ 7,723	$ 7,753
Operating lease liability, current			649	433
Operating lease liability, non-current			$ 10,005	$ 8,340
Weighted average remaining lease term (years)			9 years 8 months 15 days	9 years 5 months 8 days
Weighted average discount rate			7.60%	7.60%
Short-term lease costs			$ 152	$ 529
Operating cash flows from operating leases			$ 220	$ 1,081
Other Non-current Assets
Commitment and Contingencies
Refundable security deposit		$ 700
MARYLAND | Laboratory
Commitment and Contingencies
Number of square feet under lease agreement | item	19,700
Additional lease term	5 years
Leasehold improvement expense	$ 3,500
MARYLAND | Other Non-current Assets | Laboratory
Commitment and Contingencies
Refundable security deposit	$ 200
Maximum | In-License Agreements
Commitment and Contingencies
Percentage of future royalties for direct sales of a covered product			5.00%
Net payments received for allowable sublicenses of technology developed			7.00%
Minimum | In-License Agreements
Commitment and Contingencies
Percentage of future royalties for direct sales of a covered product			1.00%
Net payments received for allowable sublicenses of technology developed			3.00%