X0306 4 2022-09-10 0 0001827506 Talaris Therapeutics, Inc. TALS 0001378589 Fenton Mary Kay C/O TALARIS THERAPEUTICS, INC. 93 WORCESTER ST. WELLESLEY MA 02481 0 1 0 0 Chief Financial Officer Common Stock 2022-09-10 4 A 0 80000 0.00 A 81000 D The shares reported in this transaction represent restricted stock units ("RSUs") issued under the Issuer's 2021 Stock Option and Incentive Plan. Each RSU represents the contingent right to receive one share of the Issuer's Common Stock. The RSUs shall vest as to 50% of the underlying shares on July 1, 2023 and the remaining 50% on July 1, 2024, subject to the Reporting Person's continued service on each such vesting date. /s/ Mary Kay Fenton 2022-09-13