X0306 4 2022-08-22 0 0001827506 Talaris Therapeutics, Inc. TALS 0001845822 Ildstad Suzanne C/O TALARIS THERAPEUTICS, INC. 570 S. PRESTON STREET LOUISVILLE KY 40202 0 1 0 0 Chief Scientific Officer Common Stock 2022-08-22 4 S 0 525000 2.80 D 3081446 D Common Stock 1200000 I By GRAT Common Stock 654205 I See Footnote Common Stock 654205 I See Footnote These shares are held in a trust for the benefit of the Reporting Person's son. The Reporting Person's son is co-trustee of the trust. The Reporting Person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. These shares are held in a trust for the benefit of the Reporting Person's daughter. The Reporting Person's daughter is co-trustee of the trust. The Reporting Person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. /s/ Mary Kay Fenton, attorney-in-fact 2022-08-23