X0306 4 2020-12-22 0 0001680367 Shattuck Labs, Inc. STTK 0001827315 Hornblower Josiah C/O SHATTUCK LABS, INC. 1018 W. 11TH STREET, SUITE 100 AUSTIN TX 78703 1 1 0 0 Chairman Stock Option (Right to Buy) 53.02 2020-12-22 4 A 0 12954 0.00 A 2030-12-22 Common Stock 12954 12954 D This option represents a right to purchase a total of 12,954 shares of the Issuer's common stock, one quarter of which will vest on December 22, 2021, with the remaining three quarters vesting in equal monthly installments through December 22, 2024, subject to the Reporting Person's continued service to the Issuer. /s/ Erin Ator Thomson, Attorney-in-Fact for Josiah Hornblower 2020-12-28