X0306 4 2022-01-11 0 0001827087 Vigil Neuroscience, Inc. VIGL 0001867470 Northpond Ventures GP, LLC 7500 OLD GEORGETOWN ROAD, SUITE 850 BETHESDA MD 20814 0 0 1 0 0001867472 Northpond Ventures, LP 7500 OLD GEORGETOWN ROAD, SUITE 850 BETHESDA MD 20814 0 0 1 0 0001869114 Northpond Ventures GP II, LLC 7500 OLD GEORGETOWN ROAD, SUITE 850 BETHESDA MD 20814 0 0 1 0 0001869128 Northpond Ventures II, LP 7500 OLD GEORGETOWN ROAD, SUITE 850 BETHESDA MD 20814 0 0 1 0 0001867627 Rubin Michael P. 7500 OLD GEORGETOWN ROAD, SUITE 850 BETHESDA MD 20814 0 0 1 0 Common Stock 2022-01-11 4 C 0 2831520 A 2831520 I By: Northpond Ventures, LP Common Stock 2022-01-11 4 C 0 1027978 A 1027978 I By: Northpond Ventures II, LP Common Stock 2022-01-11 4 P 0 355000 14.00 A 1382978 I By: Northpond Ventures II, LP Series A Preferred Stock 2022-01-11 4 C 0 2831520 D Common Stock 2831520 0 I By: Northpond Ventures, LP Series B Preferred Stock 2022-01-11 4 C 0 1027978 D Common Stock 1027978 0 I By: Northpond Ventures II, LP Immediately prior to the closing of the initial public offering of Vigil Neuroscience, Inc. (the "Issuer"), each share of Series A Preferred Stock, par value $0.0001 per share (the "Series A Preferred Stock"), of the Issuer and each share of Series B Preferred stock, par value $0.0001 per share of the Issuer (the "Series B Preferred Stock") automatically converted on a one-for-one basis into shares of the Issuer's common stock, par value $0.0001 per share (the "Common Stock"). The right to convert the Series A Preferred Stock and Series B Preferred Stock into Common Stock had no expiration date. Northpond Ventures GP, LLC ("Northpond GP LLC") is the general partner of Northpond Ventures, LP ("Northpond Fund"), and Michael P. Rubin is the managing member of Northpond GP LLC. As a result, each of Northpond GP LLC and Mr. Rubin may be deemed to share beneficial ownership with respect to the shares held of record by Northpond Fund. Each of Northpond GP LLC and Mr. Rubin disclaim beneficial ownership of the securities reported herein, except to the extent of such Reporting Person's pecuniary interest therein, if any. Northpond Ventures GP II, LLC ("Northpond GP II LLC") is the general partner of Northpond Ventures II, LP ("Northpond Fund II"), and Michael P. Rubin is the managing member of Northpond GP II LLC. As a result, each of Northpond GP II LLC and Mr. Rubin may be deemed to share beneficial ownership with respect to the shares held of record by Northpond Fund II. Each of Northpond GP II LLC and Mr. Rubin disclaim beneficial ownership of the securities reported herein, except to the extent of such Reporting Person's pecuniary interest therein, if any. Northpond Ventures GP, LLC, By: /s/ Patrick Smerkers, Chief Financial Officer 2022-01-11 Northpond Ventures, LP, By: Northpond Ventures GP, LLC, its general partner, By: /s/ Patrick Smerkers, Chief Financial Officer 2022-01-11 Northpond Ventures GP II, LLC, By: /s/ Patrick Smerkers, Chief Financial Officer 2022-01-11 Northpond Ventures II, LP, By: Northpond Ventures GP II, LLC, its general partner, By: /s/ Patrick Smerkers, Chief Financial Officer 2022-01-11 /s/ Michael P. Rubin 2022-01-11