X0609 4 2026-09-14 0001401667 PUMA BIOTECHNOLOGY, INC. PBYI 0001827015 Cesano Alessandra false C/O PUMA BIOTECHNOLOGY, INC. 10880 WILSHIRE BLVD., SUITE 1700 LOS ANGELES CA 90024 1 1 Common Stock 2026-09-14 4 M 0 50000 2.93 A 118850 D Common Stock 2026-09-14 4 S 0 62150 9.123 D 56700 D Stock Option 2.93 2026-09-14 4 M 0 50000 0 D 2032-07-28 Common Stock 50000 50000 D Adoption date of referenced 10b5-1(c) plan is: 06-15-2026 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $9.03 to $9.2, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. The Stock Option is fully vested. /s/ Chris Culotta as attorney-in-fact for Alessandra Cesano 2026-09-16