Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Operating Loss Carryforwards [Line Items]
Deferred tax asset valuation allowance	$ 102,655	$ 85,642
Change in Valuation Allowance	$ 17,000
Percentage of Limitation Against Taxable Income	80.00%
Federal net operating loss carryforward	$ 400
State net operating loss carryforwards	$ 42,000
Tax credit limitation on use	The federal and approximately $41.5 million of state net operating losses can be carried forward indefinitely, subject to an 80% limitation against taxable income. The remaining state net operating losses of approximately $0.4 million will begin to expire in 2042, unless previously utilized.
Tax Credit Carryforward, Amount	$ 10,100
Orphan Drug Credit	$ 4,900
Operating Loss Carryforwards Expiration Period	2042
Use of annual operating loss carryforwards	Sections 382 and 383, annual use of the Company's net operating loss carryforwards may be limited in the event a cumulative change in ownership of more than 50% occurs within a three-year period.
CARES Act NOL carryover/carryback offset to taxable income.	50.00%
Unrecognized tax benefits	$ 4,582	$ 3,602	$ 1,968
Domestic Tax Authority
Operating Loss Carryforwards [Line Items]
Federal net operating loss carryforward	$ 41,500
Operating Loss Carryforwards Expiration Period	2040
Orphan drug credit carryforwards expiration period	2041
Domestic Tax Authority | Research and Development Tax Credit
Operating Loss Carryforwards [Line Items]
Federal net operating loss carryforward	$ 160,600
California Franchise Tax Board | Research and Development Tax Credit
Operating Loss Carryforwards [Line Items]
Tax Credit Carryforward, Amount	$ 3,300