Income Taxes - Schedule of Income Tax Reconciliation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Income Tax Disclosure [Abstract]
Tax computed at the federal statutory rate	$ (14,653)	$ (25,927)
State income taxes, net of federal tax benefit	(49)	(8)
Nondeductible executive compensation	369	99
Stock-based compensation	294	1,326
Research and development and orphan drug credits	(3,789)	(6,205)
Uncertain tax positions	947	1,551
Other, net	(132)	228
Valuation allowance	17,013	28,936
Income tax expense	$ 0	$ 0