Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Cash flows from operating activities
Net loss	$ (106,482)	$ (95,402)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,199	1,330
Loss on disposal of property and equipment	13	4
Gain on extinguishment of debt	0	(690)
Stock-based compensation	14,563	25,117
Accrued interest	0	3
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(2,611)	(237)
Accounts payable and accrued expenses	3,411	7,992
Right-of-use assets and lease liabilities, net	(513)	(331)
Net cash used in operating activities	(90,420)	(62,214)
Cash flows from investing activities
Purchases of property and equipment	(268)	(924)
Proceeds from sale of property and equipment	3	0
Net cash used in investing activities	(265)	(924)
Cash flows from financing activities
Payment of initial public offering costs	0	(1,911)
Proceeds from issuance of common stock, net of issuance costs	61,682	70,994
Proceeds from exercise of stock options	0	140
Proceeds from issuance of common stock under Employee Stock Purchase Plan	289	289
Payments for taxes related to net settlement of equity awards	(758)	0
Net cash provided by financing activities	61,213	69,512
Net increase (decrease) in cash and cash equivalents	(29,472)	6,374
Cash and cash equivalents, beginning of period	244,979	238,605
Cash and cash equivalents, end of period	215,507	244,979
Supplemental disclosure of non-cash investing and financing activities
Property and equipment additions included in accounts payable and accrued expenses	1	1
Tax related to net settlement of equity award included in accounts payable and accrued expenses	$ 67	$ 291