Collaboration, license and option agreements - Additional Information (Details) - USD ($) $ in Thousands		12 Months Ended
	Nov. 18, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2019
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration Amendment Date				2019-03
Revenues			$ 300
Liability to licensor		$ 19,806	19,806
BeiGene
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration Amendment Date		2021-11
Upfront Non-Refundable Payment				$ 25,000
Revenues		$ 0
License termination information, Description	In the event the license is terminated, the liability will be extinguished with no further payment to BeiGene.
Current portion of deferred revenue	$ 19,800
Liability to licensor		$ 19,800	$ 19,800