Stockholders' equity - Schedule of Stock-based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Class Of Stock [Line Items]
Stock-based compensation	$ 14,563	$ 25,117
Research and Development Expense
Class Of Stock [Line Items]
Stock-based compensation	5,419	4,688
General and Administrative Expense
Class Of Stock [Line Items]
Stock-based compensation	$ 9,144	$ 20,429