Collaboration, license and option agreements - Additional Information (Details) - USD ($) $ in Thousands		1 Months Ended	12 Months Ended
	Nov. 18, 2021	Dec. 31, 2015	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration Amendment Date			2019-12
Upfront Non-Refundable Payment					$ 20,000
Transaction Price Of The Agreement					25,000
Revenues			$ 300
Current portion of deferred revenue			0	$ 19,806
Liability to licensor			$ 19,806	0
BeiGene
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration Amendment Date			2020-10
Reimbursement Of Manufacturing Costs					5,000
Revenues			$ 0	400	5,200
License termination information, Description	In the event the license is terminated, the liability will be extinguished with no further payment to BeiGene.
Current portion of deferred revenue	$ 19,800			$ 19,800
Liability to licensor			$ 19,800
Pfizer Inc
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues					$ 500
License and option agreement payment		$ 1,000
Collaboration agreement end date			2019-12
Collaboration agreement duration			4 years