X0306 4 2022-06-15 0 0001826457 Monte Rosa Therapeutics, Inc. GLUE 0001816465 Blackwell Kimberly MONTE ROSA THERAPEUTICS, INC. 645 SUMMER STREET, SUITE 102 BOSTON MA 02210 1 0 0 0 Stock Option (Right to Buy) 7.66 2022-06-15 4 A 0 15000 0.00 A 2032-06-14 Common Stock 15000 15000 D The shares subject to this option shall vest and become exercisable in full upon the earlier to occur of (i) June 15, 2023 or (ii) the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service at such time. /s/ Ajim Tamboli, Attorney-in-Fact 2022-06-16